The Johns Hopkins University.
J Cogn Neurosci. 1997 May;9(3):409-17. doi: 10.1162/jocn.1997.9.3.409.
Although substantial progress has been made in characterizing the cognitive processes involved in simple arithmetic, the localization of these processes in the brain is not yet well understood. In this article we consider the localization of a specific arithmetic process, the retrieval of arithmetic table facts from memory. We report a single-patient study in which cortical stimulation was used to create transient disruption of brain activity in localized regions of the cortex. We show that stimulation at a left parietal site impaired performance on simple multiplication problems and further that the impairment reflected stimulation-induced disruption of arithmetic fact retrieval. Our findings support the hypothesis (e.g., Warrington, 1982) that the left parietal lobe is implicated in the arithmetic fact retrieval process.
尽管在刻画简单算术所涉及的认知过程方面已经取得了实质性的进展，但这些过程在大脑中的定位仍未得到很好的理解。在本文中，我们考虑了一个特定的算术过程的定位，即从记忆中检索算术表事实。我们报告了一项单例患者研究，其中使用皮质刺激来创建大脑皮质局部区域的短暂活动中断。我们表明，刺激左顶叶部位会损害简单乘法问题的表现，进一步表明损害反映了刺激诱导的算术事实检索中断。我们的发现支持了这样一种假设（例如，Warrington，1982），即左顶叶与算术事实检索过程有关。
