月经周期对罗库溴铵注射痛的影响。
Effects of the menstrual cycle on injection pain due to rocuronium.
机构信息
Department of Anesthesiology and Reanimation, Kecioren Training and Research Hospital, Ankara, Turkey.
Department of Anesthesiology and Reanimation, Gulhane Medical Faculty, Ankara, Turkey.
出版信息
J Clin Anesth. 2013 Aug;25(5):399-402. doi: 10.1016/j.jclinane.2013.02.007. Epub 2013 Aug 17.
STUDY OBJECTIVE
To investigate the effect of the menstrual cycle on rocuronium injection pain.
DESIGN
Prospective, randomized, double-blinded study.
SETTING
Academic medical center.
PATIENTS
80 ASA physical status 1 and 2 women scheduled for elective surgery with general anesthesia.
MEASUREMENTS
Patients were divided into two groups according to their time in the menstrual cycle. Forty patients at days 8 to 12 of the menstrual cycle were considered to be at the follicular phase (Group F), and 40 patients at days 20 to 24 of the menstrual cycle were considered to be at the luteal phase (Group L).Withdrawal movements were recorded.
MAIN RESULTS
Overall frequency of withdrawal movements was significantly higher in Group L than Group F (P < 0.001). The mean withdrawal movement score was 1.77 ± 0.76 in Group L and 0.52 ± 0.67 in Group F.
CONCLUSION
Menstrual cycle phases affect the severity of rocuronium injection pain. Women exhibit greater pain sensitivity from rocuronium injection in the luteal phase than the follicular phase.
研究目的
探讨月经周期对罗库溴铵注射痛的影响。
设计
前瞻性、随机、双盲研究。
地点
学术医疗中心。
患者
80 名 ASA 身体状况 1 级和 2 级，拟行全身麻醉下择期手术的女性。
测量
根据月经周期的时间，患者被分为两组。月经周期第 8 至 12 天的 40 名患者被认为处于卵泡期（F 组），月经周期第 20 至 24 天的 40 名患者被认为处于黄体期（L 组）。记录撤回运动。
主要结果
L 组的撤回运动次数明显高于 F 组（P<0.001）。L 组的平均撤回运动评分为 1.77±0.76，F 组为 0.52±0.67。
结论
月经周期阶段影响罗库溴铵注射痛的严重程度。黄体期女性对罗库溴铵注射的疼痛敏感性高于卵泡期。
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