Department of Psychology, Peking University, Beijing, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Biol Psychol. 2013 Oct;94(2):380-7. doi: 10.1016/j.biopsycho.2013.08.003. Epub 2013 Aug 18.
Oxytocin (OT) influences how humans process information about others. Whether OT affects the processing of information about oneself remains unknown. Using a double-blind, placebo-controlled within-subject design, we recorded event-related potentials (ERPs) from adults during trait judgments about oneself and a celebrity and during judgments on word valence, after intranasal OT or placebo administration. We found that OT vs. placebo treatment reduced the differential amplitudes of a fronto-central positivity at 220-280 ms (P2) during self- vs. valence-judgments. OT vs. placebo treatment tended to reduce the differential amplitude of a late positive potential at 520-1000 ms (LPP) during self-judgments but to increase the differential LPP amplitude during other-judgments. OT effects on the differential P2 and LPP amplitudes to self- vs. celebrity-judgments were positively correlated with a measure of interdependence of self-construals. Thus OT modulates the neural correlates of self-referential processing and this effect varies as a function of interdependence.
催产素（OT）影响人类处理他人信息的方式。OT 是否会影响对自身信息的处理尚不清楚。我们采用双盲、安慰剂对照的被试内设计，在成年人经鼻给予 OT 或安慰剂前后，记录特质判断自身和名人特质时以及词语 valence 判断时的事件相关电位（ERPs）。我们发现，OT 处理与安慰剂处理相比，在自我判断和 valence 判断时，220-280ms（P2）的额中央正性波的差异幅度降低。OT 处理与安慰剂处理相比，在自我判断时，晚期正性电位（LPP）的差异幅度有降低的趋势，但在他人判断时，差异 LPP 幅度增加。OT 对自我判断和名人判断的差异 P2 和 LPP 幅度的影响与自我构念的相互依存性测量呈正相关。因此，OT 调节自我参照加工的神经相关物，而这种影响随相互依存性的变化而变化。
