Hegde Mithra N, Hegde Nidarsh D, Ashok Aparna, Shetty Shilpa
Department of Conservative Dentistry and Endodontics, A.B.S.M.I.D.S, Mangalore, Karnataka, India.
Indian J Dent Res. 2013 Mar-Apr;24(2):164-7. doi: 10.4103/0970-9290.116670.
Oxidative stress is defined as an imbalance between the production of reactive oxygen species and antioxidant defense systems which are widely recognized as an important feature of many diseases including dental caries, suggesting that total antioxidant status may be of importance in determining the progression of caries.
The aim of this study was to estimate the total antioxidant capacity (TAC) in saliva and serum of caries-free and caries-active adults and to correlate the TAC level with DMFT index (D = decayed, M = missing, F = filled, T = teeth).
The present study included 100 healthy adults who were divided into four groups: Control, group I, group II, and group III, with a DMFT index 0, <3, <10, and >10, respectively.
Saliva and serum samples were collected from all the four groups. The TAC of saliva and serum was estimated by phosphomolybdenum method.
One-way analysis of variance (ANOVA) was used to compare the TAC of saliva and serum. Only differences with "P" < 0.05 were considered statistically significant.
The mean TAC level of both saliva and serum increased significantly (P < 0.001) with the DMFT index.
Total antioxidant capacity of saliva has a linear relation with caries, i.e., as the severity of caries increases, the TAC level also increases.
氧化应激被定义为活性氧生成与抗氧化防御系统之间的失衡，这一失衡被广泛认为是包括龋齿在内的许多疾病的一个重要特征，这表明总抗氧化状态在确定龋齿进展中可能具有重要意义。
本研究的目的是评估无龋和患龋成年人唾液和血清中的总抗氧化能力（TAC），并将TAC水平与DMFT指数（D = 龋坏，M = 缺失，F = 充填，T = 牙齿）相关联。
本研究纳入100名健康成年人，他们被分为四组：对照组、第一组、第二组和第三组，DMFT指数分别为0、<3、<10和>10。
从所有四组中采集唾液和血清样本。唾液和血清的TAC通过磷钼酸法进行评估。
采用单因素方差分析（ANOVA）比较唾液和血清的TAC。仅“P”<0.05的差异被认为具有统计学意义。
唾液和血清的平均TAC水平均随DMFT指数显著升高（P < 0.001）。
唾液的总抗氧化能力与龋齿呈线性关系，即随着龋齿严重程度增加，TAC水平也升高。
