Otomaru Konosuke, Saito Shun, Endo Karura, Kohiruimaki Masayuki, Fukuyama Shin-Ichi, Ohtsuka Hiromichi
Kagoshima Prefectural Federation of Agricultural Mutual Aid Associations, Kagoshima 891-0132, Japan.
J Vet Med Sci. 2013 Dec 30;75(12):1671-3. doi: 10.1292/jvms.13-0215. Epub 2013 Aug 20.
We investigated the effect of supplemental vitamin E on antibody titer against bovine herpesvirus-1 (BHV-1) in Japanese Black calves after vaccination with modified live virus. Thirty calves kept at the same farm were studied. They were divided into two groups; fifteen calves received 300 IU/day of vitamin E orally from 1 to 3 months of age (VE Group), and the other fifteen calves did not receive vitamin E supplement (Control Group). BHV-1 modified live vaccine was injected twice to all calves when they were 2 and 3 months of age. Following the vaccination, serum vitamin E concentration and neutralizing antibody titer to BHV-1 were measured over time. VE Group showed higher serum vitamin E at 2, 3 and 4 months of age compared to Control Group (P<0.05). The antibody titer in Control Group was the highest at 1 month of age, and it gradually decreased until 4 months of age. VE Group showed increase in antibody titer at 4 months of age resulting in significant difference (P<0.01) from Control Group. This study demonstrated that vitamin E supplementation to Japanese Black calves could increase antibody production after the second modified live BHV-1 vaccination.
我们研究了在日本黑牛犊接种牛疱疹病毒1型（BHV-1）活疫苗后，补充维生素E对其抗体滴度的影响。研究对象为同一农场饲养的30头犊牛。将它们分为两组，15头犊牛从1月龄至3月龄每天口服300国际单位的维生素E（维生素E组），另外15头犊牛不补充维生素E（对照组）。所有犊牛在2月龄和3月龄时各注射一次BHV-1活疫苗。接种疫苗后，定期测量血清维生素E浓度和针对BHV-1的中和抗体滴度。与对照组相比，维生素E组在2月龄、3月龄和4月龄时血清维生素E水平更高（P<0.05）。对照组的抗体滴度在1月龄时最高，随后逐渐下降至4月龄。维生素E组在4月龄时抗体滴度升高，与对照组相比有显著差异（P<0.01）。本研究表明，给日本黑牛犊补充维生素E可在第二次接种BHV-1活疫苗后提高抗体产生水平。
