Reddy P G, Morrill J L, Minocha H C, Stevenson J S
J Dairy Sci. 1987 May;70(5):993-9. doi: 10.3168/jds.S0022-0302(87)80104-2.
Thirty-two Holstein heifer calves, eight per group, were fed 0, 125, 250 or 500 IU/d of supplemental vitamin E/calf, from birth to 24 wk of age, in order to determine the effect on their immune responses. Overall mean lymphocyte blastogenic responses to various T-cell and B-cell mitogens were higher in supplemented calves than in control calves. Mean concentrations of cortisol in serum were lower in all supplemented calves than in control calves. Antibovine herpes-virus type 1 antibody titer (IgG) at 8 and 9 wk, in response to a commercial modified-live intranasal vaccine at 7 wk, was similar in all treatment groups. At 24 wk, in response to a booster at 21 wk, titer was higher in calves given 125 IU of vitamin E/d than in control calves. Based on the concentrations used, it is concluded that supplementation of conventional rations with 125 IU of vitamin E/d may maximize immune responses in calves and may be cost effective.
32头荷斯坦小母牛犊牛，每组8头，从出生到24周龄，每头犊牛每天分别饲喂0、125、250或500国际单位的维生素E补充剂，以确定其对免疫反应的影响。补充维生素E的犊牛对各种T细胞和B细胞有丝分裂原的总体平均淋巴细胞增殖反应高于对照犊牛。所有补充维生素E的犊牛血清皮质醇的平均浓度均低于对照犊牛。在第8周和第9周时，所有处理组对7周龄时接种的商用改良活鼻内疫苗产生的抗1型牛疱疹病毒抗体滴度（IgG）相似。在第24周时，对21周龄时加强免疫的反应中，每天给予125国际单位维生素E的犊牛的抗体滴度高于对照犊牛。根据所使用的浓度得出结论，在传统日粮中每天补充125国际单位的维生素E可能会使犊牛的免疫反应最大化，并且可能具有成本效益。
