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本文引用的文献

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Anti-CTLA-4 antibodies of IgG2a isotype enhance antitumor activity through reduction of intratumoral regulatory T cells.IgG2a 同种型的抗 CTLA-4 抗体通过减少肿瘤内调节性 T 细胞增强抗肿瘤活性。
Cancer Immunol Res. 2013 Jul;1(1):32-42. doi: 10.1158/2326-6066.CIR-13-0013. Epub 2013 Apr 7.
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Controlled local delivery of CTLA-4 blocking antibody induces CD8+ T-cell-dependent tumor eradication and decreases risk of toxic side effects.CTLA-4 阻断抗体的局部控制递送诱导 CD8+ T 细胞依赖性肿瘤消除，并降低毒性副作用风险。
Clin Cancer Res. 2013 Oct 1;19(19):5381-9. doi: 10.1158/1078-0432.CCR-12-0781. Epub 2013 Jun 20.
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Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.在单一部位耗尽肿瘤特异性 Tregs 可消除播散性肿瘤。
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Nivolumab plus ipilimumab in advanced melanoma.纳武利尤单抗联合伊匹单抗治疗晚期黑色素瘤。
N Engl J Med. 2013 Jul 11;369(2):122-33. doi: 10.1056/NEJMoa1302369. Epub 2013 Jun 2.
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Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.抗 PD-1 抗体在癌症中的安全性、活性和免疫相关性。
N Engl J Med. 2012 Jun 28;366(26):2443-54. doi: 10.1056/NEJMoa1200690. Epub 2012 Jun 2.
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Cancer immunotherapy comes of age.癌症免疫疗法崭露头角。
Nature. 2011 Dec 21;480(7378):480-9. doi: 10.1038/nature10673.
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Cancer immunotherapy comes of age.癌症免疫疗法走向成熟。
J Clin Oncol. 2011 Dec 20;29(36):4828-36. doi: 10.1200/JCO.2011.38.0899. Epub 2011 Oct 31.
8
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication.改变癌症免疫编辑的平衡点：从肿瘤耐受到消除。
Immunol Rev. 2011 May;241(1):104-18. doi: 10.1111/j.1600-065X.2011.01007.x.
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Improved survival with ipilimumab in patients with metastatic melanoma.Ipilimumab 改善转移性黑色素瘤患者的生存。
N Engl J Med. 2010 Aug 19;363(8):711-23. doi: 10.1056/NEJMoa1003466. Epub 2010 Jun 5.
10
CTLA-4 control over Foxp3+ regulatory T cell function.细胞毒性T淋巴细胞相关抗原4对叉头框蛋白3阳性调节性T细胞功能的调控
Science. 2008 Oct 10;322(5899):271-5. doi: 10.1126/science.1160062.

瘤内抗 CTLA-4 治疗：提高疗效，同时避免毒性。

Intratumoral anti-CTLA-4 therapy: enhancing efficacy while avoiding toxicity.

机构信息

Authors' Affiliations: Department of Medicine, Division of Oncology, Stanford University, Stanford, California; and Centre de Recherche en Cancérologie de Lyon (CRCL), UMR INSERM U1052 CNRS 5286, Centre Léon Bérard, Université de Lyon, Lyon, France.

出版信息

Clin Cancer Res. 2013 Oct 1;19(19):5261-3. doi: 10.1158/1078-0432.CCR-13-1923. Epub 2013 Aug 21.

DOI:10.1158/1078-0432.CCR-13-1923
PMID:23965900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3817012/
Abstract

Systemic administration of the checkpoint blockade antibody anti-CTLA4 results in severe autoimmune toxicity, limiting its clinical efficacy. Fransen and colleagues show here that peritumoral delivery of low doses of this immunomodulatory drug can trigger a systemic antitumor immune response while preventing the toxicity against other organs.

摘要

全身性给予检查点阻断抗体抗 CTLA4 会导致严重的自身免疫毒性，限制其临床疗效。Fransen 及其同事在此表明，肿瘤周围给予低剂量的这种免疫调节剂药物可以触发全身性抗肿瘤免疫反应，同时防止对其他器官的毒性。