Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.
Mar Drugs. 2013 Aug 21;11(8):3068-76. doi: 10.3390/md11083068.
Five new anthranilic acid derivatives, penipacids A-E (1-5), together with one known analogue (6), which was previously synthesized, were characterized from the ethyl acetate extract of the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated mainly by extensive NMR spectroscopic and mass spectrometric analysis. The cytotoxicity and antimicrobial activity of the isolated compounds were evaluated. Compounds 1, and 5 exhibited inhibitory activity against human colon cancer RKO cell line, while compound 6 displayed cytotoxic activity against Hela cell line.
从海洋沉积物来源的真菌青霉（Penicillium paneum）SD-44 的乙酸乙酯提取物中分离得到了五个新的邻氨基苯甲酸衍生物，分别命名为 penipacids A-E（1-5），以及一个先前合成的已知类似物（6）。通过广泛的 NMR 光谱和质谱分析确定了它们的结构。对分离得到的化合物进行了细胞毒性和抗菌活性评价。化合物 1 和 5 对人结肠癌细胞系 RKO 具有抑制活性，而化合物 6 对 Hela 细胞系具有细胞毒性。
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