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一种真菌 sp. SCSIO sof101 中的麦考酚酸衍生物。

A mycophenolic acid derivative from the fungus sp. SCSIO sof101.

机构信息

Chongqing Center For Drug Safety Evaluation, Chongqing Academy of Chinese Materia Medica, Chongqing, China.

出版信息

Nat Prod Res. 2020 May;34(9):1206-1212. doi: 10.1080/14786419.2018.1553881. Epub 2019 Feb 13.

Abstract

Mycophenolic acid (MPA) is a group of metabolite derived from several species of , which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (), was isolated from the marine derived fungus sp. SCSIO sof101, along with seven known compounds (). Their structures were elucidated based on the HR-ESI-MS and NMR data. Moreover, the H and C NMR data of compound and the C NMR data of compound are reported. Compounds , and exhibited weak activities against (clinical isolation number 100385570) and (clinical isolation number 100069).

摘要

麦考酚酸(MPA)是一类从几种青霉属衍生而来的代谢物,具有很强的生物活性。在这项研究中,从海洋来源真菌棘孢木霉 SCSIO sof101 中分离得到 MPA 化合物的一个新衍生物,命名为 penicacid D(),同时还分离得到了七个已知化合物()。根据高分辨电喷雾电离质谱(HR-ESI-MS)和核磁共振(NMR)数据鉴定了它们的结构。此外,还报道了化合物的 H 和 C NMR 数据以及化合物的 C NMR 数据。化合物、和对临床分离株(100385570)和(100069)表现出较弱的抑制活性。

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