埃塞俄比亚西南部结核病/艾滋病病毒合并感染患者的死亡预测因素：一项病例对照研究
Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest Ethiopia: A Case-Control Study.
作者信息
Deribe Kebede, Yami Alemeshet, Deribew Amare, Mesfin Nebiyu, Colebunders Robert, Van Geertruyden Jean Pierre, Woldie Mirkuzie, Maja Todd
机构信息
Department of Epidemiology, Jimma University, Jimma, Ethiopia
Department of Internal Medicine, Jimma University, Jimma, Ethiopia.
出版信息
J Int Assoc Provid AIDS Care. 2015 May-Jun;14(3):269-73. doi: 10.1177/2325957413500528. Epub 2013 Aug 21.
Abstract
BACKGROUND
Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfected patients.
METHODS
We conducted an unmatched case-control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfected patients who were alive during the end of the follow-up period.
RESULTS
Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfected patients.
CONCLUSION
Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
摘要
背景
结核病仍然是艾滋病毒/艾滋病感染者最常见的死因。本研究的目的是确定结核病/艾滋病毒合并感染患者的死亡预测因素。
方法
我们在一组接受抗逆转录病毒治疗（ART）的结核病/艾滋病毒合并感染的成年人中进行了一项非匹配病例对照研究。病例包括在此期间死亡的69例结核病/艾滋病毒合并感染患者。对于每例病例，我们选择了3例（共207例）在随访期结束时仍存活的结核病/艾滋病毒合并感染患者。
结果
男性（比值比[OR]=2.04，95%置信区间[CI]：1.04 - 4.02）、入组时卧床不起（OR = 2.84，95%CI：1.17 - 6.89）以及开始抗逆转录病毒治疗期间咳嗽超过2周（OR = 4.75，95%CI：2.14 - 10.56）是结核病/艾滋病毒合并感染患者死亡的最佳预测因素。
结论
结核病/艾滋病毒合并感染患者的死亡占该队列中相当数量的死亡病例。对抗逆转录病毒治疗开始时咳嗽且功能状态差的患者应严格随访以降低死亡率。
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