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Predictors of mortality among HIV infected patients taking antiretroviral treatment in Ethiopia: a retrospective cohort study.在埃塞俄比亚接受抗逆转录病毒治疗的 HIV 感染患者的死亡率预测因素：一项回顾性队列研究。
AIDS Res Ther. 2012 May 18;9(1):15. doi: 10.1186/1742-6405-9-15.
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Incidence of tuberculosis and early mortality in a large cohort of HIV infected patients receiving antiretroviral therapy in a tertiary hospital in Addis Ababa, Ethiopia.在埃塞俄比亚亚的斯亚贝巴的一家三级医院中，接受抗逆转录病毒治疗的大量 HIV 感染患者中结核病的发病率和早期死亡率。
Trans R Soc Trop Med Hyg. 2012 Jun;106(6):363-70. doi: 10.1016/j.trstmh.2012.03.002. Epub 2012 Apr 20.
3
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Mortality and associated risk factors in a cohort of tuberculosis patients treated under DOTS programme in Addis Ababa, Ethiopia.在埃塞俄比亚亚的斯亚贝巴，一项直接督导下的短程化疗（DOTS）项目中治疗的结核患者队列的死亡率及其相关危险因素。
BMC Infect Dis. 2011 May 16;11:127. doi: 10.1186/1471-2334-11-127.
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Tuberculosis and human immunodeficiency virus co-infections and their predictors at a hospital-based HIV/AIDS clinic in Uganda.乌干达一家医院艾滋病诊所中结核病与人免疫缺陷病毒合并感染及其预测因素。
Int J Tuberc Lung Dis. 2010 Dec;14(12):1621-8.
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HIV infection-associated tuberculosis: the epidemiology and the response.HIV 感染相关结核病：流行病学与应对。
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Who has access to counseling and testing and anti-retroviral therapy in Malawi - an equity analysis.在马拉维，谁可以获得咨询、检测和抗逆转录病毒治疗服务——公平性分析。
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Trans R Soc Trop Med Hyg. 2007 Sep;101(9):893-8. doi: 10.1016/j.trstmh.2007.04.023. Epub 2007 Jun 26.
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Prevalence, incidence and mortality associated with tuberculosis in HIV-infected patients initiating antiretroviral therapy in rural Uganda.乌干达农村地区开始接受抗逆转录病毒治疗的艾滋病毒感染患者中与结核病相关的患病率、发病率和死亡率。
AIDS. 2007 Mar 30;21(6):713-9. doi: 10.1097/QAD.0b013e328013f632.
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The impact of malnutrition on survival and the CD4 count response in HIV-infected patients starting antiretroviral therapy.营养不良对开始接受抗逆转录病毒治疗的HIV感染患者的生存及CD4细胞计数反应的影响。
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埃塞俄比亚西南部结核病/艾滋病病毒合并感染患者的死亡预测因素：一项病例对照研究

Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest Ethiopia: A Case-Control Study.

作者信息

Deribe Kebede, Yami Alemeshet, Deribew Amare, Mesfin Nebiyu, Colebunders Robert, Van Geertruyden Jean Pierre, Woldie Mirkuzie, Maja Todd

机构信息

Department of Epidemiology, Jimma University, Jimma, Ethiopia

Department of Internal Medicine, Jimma University, Jimma, Ethiopia.

出版信息

J Int Assoc Provid AIDS Care. 2015 May-Jun;14(3):269-73. doi: 10.1177/2325957413500528. Epub 2013 Aug 21.

DOI:10.1177/2325957413500528
PMID:23966102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3928041/
Abstract

BACKGROUND

Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfected patients.

METHODS

We conducted an unmatched case-control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfected patients who were alive during the end of the follow-up period.

RESULTS

Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfected patients.

CONCLUSION

Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.

摘要

背景

结核病仍然是艾滋病毒/艾滋病感染者最常见的死因。本研究的目的是确定结核病/艾滋病毒合并感染患者的死亡预测因素。

方法

我们在一组接受抗逆转录病毒治疗（ART）的结核病/艾滋病毒合并感染的成年人中进行了一项非匹配病例对照研究。病例包括在此期间死亡的69例结核病/艾滋病毒合并感染患者。对于每例病例，我们选择了3例（共207例）在随访期结束时仍存活的结核病/艾滋病毒合并感染患者。

结果

男性（比值比[OR]=2.04，95%置信区间[CI]：1.04 - 4.02）、入组时卧床不起（OR = 2.84，95%CI：1.17 - 6.89）以及开始抗逆转录病毒治疗期间咳嗽超过2周（OR = 4.75，95%CI：2.14 - 10.56）是结核病/艾滋病毒合并感染患者死亡的最佳预测因素。

结论

结核病/艾滋病毒合并感染患者的死亡占该队列中相当数量的死亡病例。对抗逆转录病毒治疗开始时咳嗽且功能状态差的患者应严格随访以降低死亡率。