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Revealing targeted therapeutic opportunities in triple-negative breast cancers: a new strategy.

作者信息

Poage Graham M, Hartman Zachary C, Brown Powel H

机构信息

Department of Clinical Cancer Prevention; The University of Texas MD Anderson Cancer Center; Houston, TX USA.

出版信息

Cell Cycle. 2013 Sep 1;12(17):2705-6. doi: 10.4161/cc.25871. Epub 2013 Jul 30.

DOI:10.4161/cc.25871
PMID:23966168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3899176/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e826/3899176/a49c1350c444/cc-12-2705-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e826/3899176/a49c1350c444/cc-12-2705-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e826/3899176/a49c1350c444/cc-12-2705-g1.jpg

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本文引用的文献

1
Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8.三阴性乳腺癌细胞的生长依赖于前炎症细胞因子白细胞介素-6 和白细胞介素-8 的协调自分泌表达。
Cancer Res. 2013 Jun 1;73(11):3470-80. doi: 10.1158/0008-5472.CAN-12-4524-T. Epub 2013 Apr 30.
2
Comprehensive molecular portraits of human breast tumours.人类乳腺肿瘤的全面分子特征图谱。
Nature. 2012 Oct 4;490(7418):61-70. doi: 10.1038/nature11412. Epub 2012 Sep 23.
3
Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population.
Integrated analysis of differentially expressed genes and pathways in triple‑negative breast cancer.
三阴性乳腺癌中差异表达基因和通路的综合分析
Mol Med Rep. 2017 Mar;15(3):1087-1094. doi: 10.3892/mmr.2017.6101. Epub 2017 Jan 4.
4
siRNA-mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation and migration.小干扰RNA介导的Ⅳ型胶原α2（COL4A2）信使核糖核酸抑制可抑制三阴性乳腺癌细胞的增殖和迁移。
Oncotarget. 2017 Jan 10;8(2):2585-2593. doi: 10.18632/oncotarget.13716.
5
Rapid Extensive Recurrence of Triple Negative Breast Cancer: Are Both Therapy and Cancer Biology the Culprit?三阴性乳腺癌的快速广泛复发：治疗与癌症生物学都是罪魁祸首吗？
J Clin Med Res. 2016 Feb;8(2):162-7. doi: 10.14740/jocmr2365w. Epub 2015 Dec 28.
6
Molecular Features of Triple Negative Breast Cancer: Microarray Evidence and Further Integrated Analysis.三阴性乳腺癌的分子特征：微阵列证据及进一步的综合分析
PLoS One. 2015 Jun 23;10(6):e0129842. doi: 10.1371/journal.pone.0129842. eCollection 2015.
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Aberrant expression and potential therapeutic target of lysophosphatidic acid receptor 3 in triple-negative breast cancers.溶血磷脂酸受体3在三阴性乳腺癌中的异常表达及潜在治疗靶点
Clin Exp Med. 2015 Aug;15(3):371-80. doi: 10.1007/s10238-014-0306-5. Epub 2014 Sep 11.
IL6 炎症环的激活通过扩大癌症干细胞群体介导曲妥珠单抗耐药性在 HER2+乳腺癌中。
Mol Cell. 2012 Aug 24;47(4):570-84. doi: 10.1016/j.molcel.2012.06.014. Epub 2012 Jul 19.
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Nature. 2012 Apr 4;486(7403):395-9. doi: 10.1038/nature10933.
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The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors.JAK2/STAT3 信号通路对于人肿瘤中 CD44+CD24- 干细胞样乳腺癌细胞的生长是必需的。
J Clin Invest. 2011 Jul;121(7):2723-35. doi: 10.1172/JCI44745.
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Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
8
Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer.鉴定新型激酶靶点用于治疗雌激素受体阴性乳腺癌。
Clin Cancer Res. 2009 Oct 15;15(20):6327-40. doi: 10.1158/1078-0432.CCR-09-1107. Epub 2009 Oct 6.