Institut de Recherches Cliniques de Montréal; Montréal, Québec, Canada.
Cell Cycle. 2013 Sep 1;12(17):2744-52. doi: 10.4161/cc.25825. Epub 2013 Aug 5.
In order to resorb the mineralized bone extracellular matrix, the osteoclast relies on the generation of a resorption lacuna characterized by the presence of specific proteases and a low pH. Hence, bone resorption by osteoclasts is highly dependent on lysosomes, the organelles specialized in intra- and extracellular material degradation. This is best illustrated by the fact that multiple forms of human osteopetrosis are caused by mutations in genes encoding for lysosomal proteins. Yet, until recently, the molecular mechanisms regulating lysosomal biogenesis and function in osteoclasts were poorly understood. Here we review the latest developments in the study of lysosomal biogenesis and function in osteoclasts with an emphasis on the transcriptional control of these processes.
为了吸收矿化的骨细胞外基质，破骨细胞依赖于形成一个特征为存在特定蛋白酶和低 pH 值的吸收腔。因此，破骨细胞的骨吸收高度依赖于溶酶体，溶酶体是专门用于细胞内和细胞外物质降解的细胞器。这一点最好地说明了这样一个事实，即多种形式的人类骨质增生症是由编码溶酶体蛋白的基因突变引起的。然而，直到最近，破骨细胞中溶酶体生物发生和功能的分子机制还知之甚少。本文综述了溶酶体生物发生和功能在破骨细胞中的最新研究进展，重点介绍了这些过程的转录控制。
