Ma Huali, Lin Yongbin, Wang Liang, Rao Huilan, Xu Guangchuan, He Youjian, Liang Ying
Department of Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China; State Key Laboratory of Oncology in South China/Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
Head Neck. 2014 Sep;36(9):1305-12. doi: 10.1002/hed.23450. Epub 2014 Jan 16.
Lymphoepithelioma-like carcinoma (LELC) in the salivary glands is a rare but unique malignancy.
Sixty-nine patients with salivary gland LELC with long-term follow-up were reviewed for this study.
There were 52 cases in the parotid gland and 17 cases in the submandibular gland. All patients underwent complete tumor excision, 41 underwent neck dissection, and 39 received postoperative radiotherapy. The 5-year, 10-year, and 15-year overall survival (OS) rates were 90%, 75%, and 54%, respectively. Patients with higher neutrophil/lymphocyte ratio (NLR ≥ 4.0) and advanced stage (stage III and IV) had significantly poorer OS. Patients who received postoperative radiotherapy had significantly better relapse-free survival (RFS). In multivariate analysis, stage, NLR, and neck dissection were associated independently with OS, whereas stage and postoperative radiotherapy were associated independently with RFS.
Salivary gland LELC is a rare malignancy with a better prognosis that partially attributes to surgery with neck dissection and postoperative radiotherapy. Preoperative NLR is an independent prognostic factor.
涎腺淋巴上皮瘤样癌（LELC）是一种罕见但独特的恶性肿瘤。
本研究回顾了69例接受长期随访的涎腺LELC患者。
腮腺52例，颌下腺17例。所有患者均接受了肿瘤完整切除，41例行颈部清扫术，39例接受术后放疗。5年、10年和15年总生存率（OS）分别为90%、75%和54%。中性粒细胞/淋巴细胞比值较高（NLR≥4.0）和晚期（III期和IV期）患者的OS明显较差。接受术后放疗的患者无复发生存率（RFS）明显更好。多因素分析显示，分期、NLR和颈部清扫术独立与OS相关，而分期和术后放疗独立与RFS相关。
涎腺LELC是一种罕见的恶性肿瘤，预后较好，部分归因于颈部清扫术和术后放疗。术前NLR是一个独立的预后因素。
