Kallel Souha, Ayadi Sirine, Salem Noura, Zghal Mouna, Mariem Ben Ayed, Ayedi Lobna, Mnejja Malek, Boudawara Tahya, Charfeddine Ilhem
ENT Department and Research Laboratory LR23ES01, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
Department of Pathology and Research Laboratory LR18SP10, Habib Bourguiba University Hospital, University of Sfax, Sfax, Tunisia.
SAGE Open Med Case Rep. 2024 Jun 12;12:2050313X241260210. doi: 10.1177/2050313X241260210. eCollection 2024.
Primary lymphoepithelial carcinoma of the salivary glands is an exceptional oncological condition that predominantly emerges within the parotid gland. A significant prevalence of lymphoepithelial carcinoma has been reported in the Inuit population, along with an associated positive serology for Epstein-Barr virus in these endemic regions. In this paper, we present a case of primary lymphoepithelial carcinoma of the parotid gland in a 68-year-old female patient with a history of diabetes and hypertension residing in a non-endemic area. Histology plays a critical role in the definitive diagnosis, and confirming the primary origin of lymphoepithelial carcinoma after ruling out metastasis from undifferentiated nasopharyngeal carcinoma. The mainstay of treatment is a combination of surgical resection and adjuvant radiotherapy. Inoperable forms are typically managed with chemoradiotherapy.
涎腺原发性淋巴上皮癌是一种罕见的肿瘤性疾病，主要发生于腮腺。据报道，因纽特人群中淋巴上皮癌的患病率较高，且在这些流行地区，相关的血清学检测显示爱泼斯坦-巴尔病毒呈阳性。在本文中，我们报告了一例68岁女性腮腺原发性淋巴上皮癌病例，该患者有糖尿病和高血压病史，居住在非流行地区。组织学在明确诊断中起着关键作用，在排除未分化鼻咽癌转移后确认淋巴上皮癌的原发部位。治疗的主要方法是手术切除和辅助放疗相结合。无法手术的病例通常采用放化疗。
