阿德拉对成年多动症认知表现的影响。
Lobeline Effects on Cognitive Performance in Adult ADHD.
机构信息
1 University of Kentucky, Lexington, KY, USA.
2 Yaupon Therapeutics, Malvern, PA, USA.
出版信息
J Atten Disord. 2018 Dec;22(14):1361-1366. doi: 10.1177/1087054713497791. Epub 2013 Aug 21.
Abstract
OBJECTIVE
In preclinical studies, lobeline inhibited hyperactivity induced by nicotine and amphetamine, and improved performance and learning in studies utilizing radial-arm maze and spatial-discrimination water maze. This laboratory proof-of-concept study investigated lobeline as a treatment for ADHD symptoms in adults (31.11 ± 7.08 years).
METHOD
Using cognitive tasks and self-report measures, the effects of lobeline (0, 7.5, 15, or 30 mg, s.l.) and methylphenidate (0, 15, or 30 mg, p.o.) were assessed in nine volunteers with ADHD.
RESULTS
Evidence suggested that lobeline could modestly improve working memory in adults with ADHD, but no significant improvement in attention was observed. Lobeline administration was associated with mild adverse side effects (nausea).
CONCLUSION
Further investigation of lobeline on working memory may be warranted.
摘要
目的
在临床前研究中，洛贝林可抑制尼古丁和安非他命引起的过度兴奋，并在利用放射臂迷宫和空间辨别水迷宫进行的研究中提高表现和学习能力。这项实验室概念验证研究调查了洛贝林作为成人注意力缺陷多动障碍（31.11 ± 7.08 岁）症状的治疗方法。
方法
使用认知任务和自我报告措施，评估了洛贝林（0、7.5、15 或 30mg，皮下）和哌甲酯（0、15 或 30mg，口服）在 9 名患有注意力缺陷多动障碍的志愿者中的作用。
结果
有证据表明，洛贝林可适度改善患有注意力缺陷多动障碍的成年人的工作记忆，但未观察到注意力有显著改善。洛贝林给药与轻微的不良反应（恶心）相关。
结论
进一步研究洛贝林对工作记忆的影响可能是必要的。
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