Huang Jing, Duan Yunyun, Liu Sidong, Liang Peipeng, Ren Zhuoqiong, Gao Yang, Liu Yaou, Zhang Xiaojun, Lu Jie, Li Kuncheng
Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China.
Front Hum Neurosci. 2018 Dec 20;12:473. doi: 10.3389/fnhum.2018.00473. eCollection 2018.
Previous studies have revealed brain adaptations to injury that occurs in optic neuritis (ON); however, the mechanisms underlying the functional connectivity (FC) and gray matter volume (GMV) changes in ON have not been clarified. Here, 51 single attack ON patients and 45 recurrent attacks ON patients were examined using structural MRI and resting-state functional MRI (RS-fMRI), and compared to 49 age- and gender-matched healthy controls (HC). FC analysis with a seed in primary visual cortex (V1 area) was used to assess the differences among three groups. Whole brain GMV was assessed using voxel-based morphometry (VBM). Correlation analyses were performed between FC results, structural MRI and clinical variables. We found positive correlations between the Paced Auditory Serial Addition Test (PASAT) score and FC in V1 area with bilateral middle frontal gyrus. Disease duration is significantly negatively related to FC in V1 area with the left inferior parietal lobule. Compared to the HC, single attack ON patients were found to have decreased FC values in the frontal, temporal lobes, right inferior occipital gyrus, right insula, right inferior parietal lobule, and significant increased FC values in the left thalamus. Recurrent attacks ON patients had the same pattern with single attack ON. No significant differences were found in brain GMV among three groups. This study provides the imaging evidence that impairment and compensation of V1 area connectivity coexist in ON patients, and provides important insights into the underlying neural mechanisms of ON.
先前的研究已经揭示了大脑对视神经炎（ON）中发生的损伤的适应性变化；然而，ON中功能连接性（FC）和灰质体积（GMV）变化的潜在机制尚未阐明。在此，我们使用结构磁共振成像（MRI）和静息态功能磁共振成像（RS-fMRI）对51例单次发作的ON患者和45例复发发作的ON患者进行了检查，并与49名年龄和性别匹配的健康对照者（HC）进行了比较。以初级视觉皮层（V1区）为种子点进行FC分析，以评估三组之间的差异。使用基于体素的形态学测量（VBM）评估全脑GMV。对FC结果、结构MRI和临床变量进行了相关性分析。我们发现，定速听觉连续加法测验（PASAT）得分与V1区与双侧额中回的FC之间存在正相关。病程与V1区与左侧顶下小叶的FC呈显著负相关。与HC相比，单次发作的ON患者在额叶、颞叶、右侧枕下回、右侧岛叶、右侧顶下小叶的FC值降低，而在左侧丘脑的FC值显著升高。复发发作的ON患者与单次发作的ON患者具有相同的模式。三组之间的脑GMV未发现显著差异。本研究提供了影像学证据，表明ON患者中V1区连接性的损伤和代偿并存，并为ON的潜在神经机制提供了重要见解。
