Cooper T B, Simpson G M, Haher E F, Bergner P E
Arch Gen Psychiatry. 1975 Jul;32(7):903-5. doi: 10.1001/archpsyc.1975.01760250095010.
Experimental evidence showed that a higher whole blood steady state drug plasma level was achieved when a patient was given medication three times a day compared to the same total daily dose once a day. In addition, evidence indicated possible enzyme induction by butaperazine in one patient. We have demonstrated that the general stochastic theory developed to investigate the pharmacokinetics of lithium carbonate "in vivo" has more general applicability in that it applies also to butaperazine, and facilitates interpretation of findings (without blood level data) in one other drug study.
实验证据表明，与每日一次给予相同总剂量药物相比，患者每日三次给药时可达到更高的全血稳态药物血浆水平。此外，有证据表明一名患者体内可能存在丁酰拉嗪诱导的酶。我们已经证明，为研究碳酸锂“体内”药代动力学而开发的一般随机理论具有更广泛的适用性，因为它也适用于丁酰拉嗪，并且有助于解释另一项药物研究中的结果（无需血药浓度数据）。
