慢性精神分裂症患者中布他哌嗪血药浓度与血浆催乳素的关系。

Relationship of butaperazine blood levels to plasma prolactin in chronic schizophrenic patients.

作者信息

Smith R C, Tamminga C A, Crayton J W, Dekirmenjian H, Davis J M

出版信息

Psychopharmacology (Berl). 1979;66(1):29-33. doi: 10.1007/BF00431985.

DOI:10.1007/BF00431985

Abstract

The relationship of plasma prolactin to plasma or red blood cell butaperazine levels was investigated in chronic schizophrenic patients treated with clinical doses of butaperazine, both after a single acute dose of the drug and during regular, twice daily butaperazine administration. Although there was a significant curvilinear relationship between peak plasma butaperazine levels after an acute single oral dose of butaperazine and the maximum prolactin response that we measured, steady-state levels of plasma or red cell butaperazine and plasma prolactin were not related. We conclude that plasma prolactin cannot be used as a substitute for or even as a rough indicator of butaperazine blood levels in chronic schizophrenic patients being treated with clinical doses of butaperazine.

摘要

在接受临床剂量丁酰拉嗪治疗的慢性精神分裂症患者中，研究了血浆催乳素与血浆或红细胞中丁酰拉嗪水平的关系，研究时间分别为单次急性给药后以及丁酰拉嗪每日两次常规给药期间。尽管单次急性口服丁酰拉嗪后血浆丁酰拉嗪峰值水平与我们测得的最大催乳素反应之间存在显著的曲线关系，但血浆或红细胞丁酰拉嗪的稳态水平与血浆催乳素并无关联。我们得出结论，对于接受临床剂量丁酰拉嗪治疗的慢性精神分裂症患者，血浆催乳素不能用作丁酰拉嗪血药浓度的替代指标，甚至不能作为粗略指标。