临床抑郁症患者血清铜/锌超氧化物歧化酶水平升高，经锌和抗氧化剂治疗后恢复正常。
Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy.
作者信息
Russo A J
机构信息
Research Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555.
出版信息
Nutr Metab Insights. 2010 Jun 17;3:37-42. doi: 10.4137/NMI.S5044. eCollection 2010.
AIM
To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression.
SUBJECTS AND METHODS
Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs.
RESULTS
Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls.
DISCUSSION
These results suggest an association between Cu/Zn SOD serum levels and clinical depression.
目的
评估临床抑郁症患者血清铜/锌超氧化物歧化酶（SOD）浓度。
对象与方法
采用酶联免疫吸附测定法（ELISA）检测36例临床诊断为抑郁症的患者及18例健康对照者的血清铜/锌SOD浓度。
结果
抑郁症患者（伴有和不伴有继发性焦虑）的血清铜/锌SOD水平显著高于年龄和性别匹配的对照组。我们还发现，抗氧化治疗后，铜/锌SOD水平恢复至正常健康对照者的水平。
讨论
这些结果表明血清铜/锌SOD水平与临床抑郁症之间存在关联。
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