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临床抑郁症患者血清铜/锌超氧化物歧化酶水平升高，经锌和抗氧化剂治疗后恢复正常。

Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes After Zinc and Anti-oxidant Therapy.

作者信息

Russo A J

机构信息

Research Director, Health Research Institute/Pfeiffer Treatment Center, 4575 Weaver Parkway, Warrenville, Illinois 60555.

出版信息

Nutr Metab Insights. 2010 Jun 17;3:37-42. doi: 10.4137/NMI.S5044. eCollection 2010.

DOI:10.4137/NMI.S5044
PMID:23966790
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3736885/
Abstract

AIM

To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression.

SUBJECTS AND METHODS

Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs.

RESULTS

Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls.

DISCUSSION

These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

摘要

目的

评估临床抑郁症患者血清铜/锌超氧化物歧化酶（SOD）浓度。

对象与方法

采用酶联免疫吸附测定法（ELISA）检测36例临床诊断为抑郁症的患者及18例健康对照者的血清铜/锌SOD浓度。

结果

抑郁症患者（伴有和不伴有继发性焦虑）的血清铜/锌SOD水平显著高于年龄和性别匹配的对照组。我们还发现，抗氧化治疗后，铜/锌SOD水平恢复至正常健康对照者的水平。

讨论

这些结果表明血清铜/锌SOD水平与临床抑郁症之间存在关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/3736885/c7ad3592ebb2/nmi-3-2010-037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/3736885/076a6f51a995/nmi-3-2010-037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/3736885/c7ad3592ebb2/nmi-3-2010-037f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/3736885/076a6f51a995/nmi-3-2010-037f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8159/3736885/c7ad3592ebb2/nmi-3-2010-037f2.jpg

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