Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.
PLoS One. 2013 Aug 13;8(8):e70841. doi: 10.1371/journal.pone.0070841. eCollection 2013.
One of the most important carbohydrate-splitting enzymes is themaltase-glucoamylase which catalyzes the hydrolysis of alpha-glucosidic linkages. Maltase-glucoamylase inhibitors during the last few years have aroused medical interests in the treatment of diabetes. They contribute to a better understanding of the mechanism of maltase-glucoamylase. At present there are many different classes of maltase-glucoamylase inhibitors. This paper focuses on alkaloidal inhibitors of maltase-glucoamylase and structure-activity relationship (SAR) studies between them in order to discover some drugs with better efficiency and lower toxicity for treating diabetes.
其中一种最重要的碳水化合物分解酶是麦芽糖酶-葡糖苷酶，它催化α-葡萄糖苷键的水解。在过去的几年中，麦芽糖酶-葡糖苷酶抑制剂引起了医学界对糖尿病治疗的兴趣。它们有助于更好地了解麦芽糖酶-葡糖苷酶的作用机制。目前有许多不同类型的麦芽糖酶-葡糖苷酶抑制剂。本文主要关注麦芽糖酶-葡糖苷酶的生物碱抑制剂及其结构-活性关系（SAR）研究，以便发现一些治疗糖尿病的效率更高、毒性更低的药物。
