Kenney M J, Gebber G L, Barman S M, Kocsis B
Department of Pharmacology, Michigan State University, East Lansing 48824.
Am J Physiol. 1990 Sep;259(3 Pt 2):R572-8. doi: 10.1152/ajpregu.1990.259.3.R572.
Autospectral and coherence analyses were used to study the frequency-domain relationships between frontal-parietal cortical activity [electroencephalogram (EEG)] and the discharges of the interior cardiac and renal sympathetic nerves of baroreceptor-denervated and vagotomized cats anesthetized with either alpha-chloralose or pentobarbital sodium. Delta slow-wave activity in the EEG was correlated to sympathetic nerve discharge (SND) as shown by sharp peaks between 0.5 and 4 Hz in the coherence function. The relationship was stronger in chloralose- than in pentobarbital-anesthetized cats. Coherence of the two signals could be attributed to descending influences of forebrain delta slow-wave generators on sympathetic circuits, since midbrain transection preferentially reduced the power in SND at frequencies that cohered to the EEG before transection. In contrast, the power in the EEG was not reduced by midbrain transection. The relationship between cortical delta slow-wave activity and SND was stronger during than between cortical spindlelike events that lasted 1-3 s and recurred once every 5-10 s. These events were similar to cortical spindles observed during the early stages of sleep and under light barbiturate anesthesia. These observations raise the possibility that the influences of forebrain delta slow-wave generators on SND are gated by thalamic mechanisms normally involved in the sleep-wake cycle.
采用自谱分析和相干分析方法，研究了用α-氯醛糖或戊巴比妥钠麻醉的去压力感受器神经和迷走神经的猫，其额顶叶皮质活动[脑电图(EEG)]与心脏和肾脏内脏交感神经放电之间的频域关系。脑电图中的δ慢波活动与交感神经放电(SND)相关，相干函数在0.5至4Hz之间出现尖锐峰值即表明了这一点。这种关系在氯醛糖麻醉的猫中比在戊巴比妥麻醉的猫中更强。这两个信号的相干性可归因于前脑δ慢波发生器对交感神经回路的下行影响，因为中脑横断优先降低了横断前与脑电图相干频率下的SND功率。相比之下，脑电图的功率并未因中脑横断而降低。皮质δ慢波活动与SND之间的关系在持续1 - 3秒、每5 - 10秒重复一次的皮质纺锤样事件期间比在这些事件之间更强。这些事件类似于在睡眠早期和轻度巴比妥类麻醉下观察到的皮质纺锤波。这些观察结果提出了一种可能性，即前脑δ慢波发生器对SND的影响是由通常参与睡眠-觉醒周期的丘脑机制所控制的。
