Huang Z S, Varner K J, Barman S M, Gebber G L
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.
Am J Physiol. 1988 Feb;254(2 Pt 2):R249-56. doi: 10.1152/ajpregu.1988.254.2.R249.
We reported that the forebrain is responsible for a significant component (38%) of inferior cardiac postganglionic sympathetic nerve discharge (SND) in baroreceptor-denervated cats anesthetized with alpha-chloralose [Huang et al., Am. J. Physiol. 252 (Regulatory Integrative Comp. Physiol. 21): R645-R652, 1987]. The current study was initiated to assess the contribution of various diencephalic regions to the forebrain-dependent component of SND in this preparation. For this purpose, the reductions in inferior cardiac SND and blood pressure produced acutely by midbrain transection at stereotaxic plane A3 in nonlesioned control cats were compared with those in cats in which diencephalic lesions were made with radio-frequency current. Lesions of the anterior medial hypothalamus including the paraventricular nucleus failed to attenuate the decreases in SND and blood pressure produced by midbrain transection. In contrast, the effects of midbrain transection were significantly attenuated by lesions of the lateral hypothalamus (including medial forebrain bundle), posterior medial hypothalamus, or the medial thalamus. We conclude that both the hypothalamus and medial thalamus contribute to SND in anesthetized cats.
我们曾报道，在用α-氯醛糖麻醉的去压力感受器猫中，前脑对心脏节后交感神经放电（SND）减弱的显著部分（38%）负责[Huang等人，《美国生理学杂志》252（调节整合生理学21）：R645 - R652，1987]。本研究旨在评估在此制备中各种间脑区域对SND的前脑依赖性部分的贡献。为此，将在非损伤对照猫中于立体定位平面A3处急性进行中脑横断所产生的心脏SND减弱和血压降低，与用射频电流造成间脑损伤的猫中的情况进行比较。包括室旁核在内的下丘脑前内侧损伤未能减弱中脑横断所导致的SND和血压降低。相反，下丘脑外侧（包括内侧前脑束）、下丘脑后内侧或内侧丘脑的损伤显著减弱了中脑横断的效应。我们得出结论，下丘脑和内侧丘脑均对麻醉猫的SND有影响。
