Djurhuus J C, Frokjaer J, Munch Jorgensen T, Knudsen L, Pham T, Constantinou C E
Department of Surgery, Stanford University School of Medicine, California 94305.
Am J Physiol. 1990 Sep;259(3 Pt 2):R637-44. doi: 10.1152/ajpregu.1990.259.3.R637.
The influence of the voiding cycle and diuresis on the hydrodynamic pressures of the renal pelvis in the multicalyceal kidney of miniature pigs has been examined. Identification of the pressure patterns characteristic of the renal pelvis with an undisturbed pelviureteric and ureterovesical junction was emphasized. The frequency and amplitude of contractions in the renal pelvis were measured bilaterally. The patterns of renal pelvic pressure changes were interpreted during bladder filling and emptying and diuresis to evaluate the mechanisms facilitating the pressure isolation of the upper urinary tract. These studies were undertaken in the awake pig equipped with a long-term radiotelemetry implant transmitting renal pelvic and urinary bladder pressure. The results show that renal pelvic contractions are low-pressure events having an amplitude of 10.3 +/- 4.2 cmH2O and a frequency of 6.6 +/- 0.7 contractions/min. During basal hydration, the process of renal pelvic filling and emptying is active, with rhythmic pelvic contractions. The left and right renal pelvis demonstrate approximately equal frequency, 1.04:1.00, but are not synchronous. Furosemide-stimulated diuresis produces radical changes in the renal pelvis by transforming emptying from an active to passive mode and facilitating the transmission of voiding pressures and spontaneous bladder pressures to the kidney.
研究了排尿周期和利尿对小型猪多肾盂肾脏肾盂流体动力压力的影响。强调了识别肾盂在肾盂输尿管和输尿管膀胱连接未受干扰时的特征性压力模式。双侧测量肾盂收缩的频率和幅度。在膀胱充盈、排空和利尿过程中解释肾盂压力变化模式，以评估促进上尿路压力隔离的机制。这些研究是在配备长期无线电遥测植入物以传输肾盂和膀胱压力的清醒猪身上进行的。结果表明，肾盂收缩是低压事件，幅度为10.3±4.2 cmH₂O，频率为6.6±0.7次/分钟。在基础水合状态下，肾盂充盈和排空过程活跃，伴有节律性肾盂收缩。左右肾盂频率大致相等，为1.04:1.00，但不同步。速尿刺激的利尿通过将排空从主动模式转变为被动模式，并促进排尿压力和自发性膀胱压力向肾脏的传递，从而使肾盂产生根本性变化。
