Djurhuus J C, Nerstrom B, Hansen R I, Gyrd-Hansen N, Rask-Andersen H
Invest Urol. 1977 May;14(6):469-74.
Renal pelvic function of Danish Landrace pigs under anesthesia was analyzed during "normal" and forced diuresis. Measurements were made of intrapelvic pressures, electromyogram recordings were taken from the pelvis and ureter, and bolus formation was followed. During constant diuresis, pelvic activity displayed a dominant frequency which varied between individuals. When pressure rose or fell, pelvic activity increased or decreased in proportion to the speed rather than the extent of the pressure change. Thus, after furosemide administration urine flow increased and pelvic pressure rose; and in association with the pressure rise, pelvic activity increased significantly when mean pelvic activity in the phase of steep pressure rise was compared with the mean activity over the last 5 min of the observation period before induction of diuresis. Thereafter, pelvic activity decreased despite maintenance of a higher pressure plateau than that in the initial low diuresis observation period. This mode of function can be explained by reference to the characteristics of smooth muscle. Postulation of a specific pacemaker is unnecessary.
在“正常”利尿和强制利尿期间，对处于麻醉状态的丹麦长白猪的肾盂功能进行了分析。测量肾盂内压力，记录肾盂和输尿管的肌电图，并跟踪团块形成。在持续利尿期间，肾盂活动表现出个体间不同的主导频率。当压力上升或下降时，肾盂活动随压力变化速度而非变化幅度成比例增加或减少。因此，给予速尿后尿流量增加且肾盂压力升高；与压力升高相关，当将压力急剧上升阶段的平均肾盂活动与利尿诱导前观察期最后5分钟的平均活动相比较时，肾盂活动显著增加。此后，尽管维持了比初始低利尿观察期更高的压力平台，但肾盂活动仍下降。这种功能模式可通过参考平滑肌的特性来解释。无需假定特定的起搏器。
