Tarakanov A V
Anesteziol Reanimatol. 1990 May-Jun(3):23-6.
The experiments on white male rats have established that clopheline preinjection shortens the latent period and prolongs the duration of ketamine anesthesia due to alpha 2-, alpha 2- and beta 2-adrenoceptor mechanisms, respectively. An additional administration of prazosin and naloxone (0.1 mg/kg) potentiates the duration of combined clopheline and ketamine anesthesia. The duration of ketamine anesthesia alone remains unchanged in simultaneous alpha 1- and alpha 2-adrenoceptor blockade with phentolamine, however, it is prolonged in alpha 1-adrenoceptor blockade and shortened in alpha 2-adrenoceptor blockade with prazosin and yohimbine, respectively. Tachycardiac effects of ketamine are removed with clopheline due to alpha 2-adrenostimulation and beta 1-adrenoblockade with talinolol or attenuated upon reserpine administration. The combined use of clopheline and ketamine for the termination of pregnancy, as compared to combined diazepam and ketamine anesthesia, prolongs the duration of anesthesia, normalizes basic hemodynamic parameters prior to and following the injection of an anesthetic and promotes to a more adequate discontinuation of anesthesia.
对白雄性大鼠进行的实验已证实，预先注射氯苯乙胍可缩短潜伏期并延长氯胺酮麻醉的持续时间，这分别归因于α2 -、α2 -和β2 -肾上腺素能受体机制。额外给予哌唑嗪和纳洛酮（0.1毫克/千克）可增强氯苯乙胍和氯胺酮联合麻醉的持续时间。在使用酚妥拉明同时阻断α1 -和α2 -肾上腺素能受体时，单独使用氯胺酮的麻醉持续时间保持不变，然而，在分别使用哌唑嗪和育亨宾阻断α1 -肾上腺素能受体时麻醉持续时间延长，而在阻断α2 -肾上腺素能受体时麻醉持续时间缩短。由于α2 -肾上腺素能刺激以及使用他林洛尔进行β1 -肾上腺素能阻断，氯苯乙胍可消除氯胺酮的心动过速效应，或者在给予利血平后该效应减弱。与地西泮和氯胺酮联合麻醉相比，氯苯乙胍和氯胺酮联合用于终止妊娠时，可延长麻醉持续时间，使注射麻醉剂前后的基本血流动力学参数正常化，并促进麻醉更充分地停止。
