Kobayashi Ichizo
Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo.
Nihon Rinsho. 2013 Aug;71(8):1352-67.
Helicobacter pylori, a major stomach pathogen associated with gastritis, gastric/duodenal ulcer, gastric cancer and other diseases, shows extreme diversity at the genome sequence level. It is now possible to sequence whole genomes of Japanese isolates at a reasonable cost. Here I summarize what has been learned from analyzing whole H. pylori genomes. Emphasis is placed on features of East Asian strains, genome dynamics and epigenetics. I cover both long-term evolution with us Homo sapiens and short-term evolution within our bodies. I hope this guide will be helpful for decoding and analyzing H. pylori genomes of clinical isolates, especially those from Japan and other East Asian countries.
幽门螺杆菌是一种与胃炎、胃/十二指肠溃疡、胃癌及其他疾病相关的主要胃部病原体，在基因组序列水平上表现出极大的多样性。现在，以合理的成本对日本分离株的全基因组进行测序已成为可能。在此，我总结了分析幽门螺杆菌全基因组所获得的知识。重点关注东亚菌株的特征、基因组动态变化和表观遗传学。我既涵盖了与人类的长期共同进化，也包括了在人体内部的短期进化。希望本指南有助于解读和分析临床分离株的幽门螺杆菌基因组，尤其是来自日本和其他东亚国家的分离株。
