[Characteristics of hemostatic disorders in septic shock in children].

Changes at different stages of coagulation cascade have been assessed during intensive therapy of septic shock in 40 children aged 1 to 14 years. Progressing septic shock is accompanied by chronometric and structural hypocoagulation with potential hypercoagulation in transfer samples, thrombocytopenia and thrombocytopathy. Terminal stages of septic shock are characterized by profound hypocoagulation without potential hypercoagulation, predominance of antithrombin and antiaggregant blood activity with persistent depletion of antithrombin III and plasminogen. The decrement of arterio-venous difference in hemostasis parameters is typical of marked stages of the shock lung. Dynamic control over hemostasis shifts makes it possible to predict the outcome of septic shock.