Belknap J K, Derksen F J, Nickels F A, Stick J A, Robinson N E
Department of Large Animal Clinical Sciences, Michigan State University, East Lansing 48824-1214.
Am J Vet Res. 1990 Sep;51(9):1481-7.
Upper airway flow mechanics and arterial blood gas measurements were used to assess the efficacy of subtotal arytenoidectomy for treatment of induced left laryngeal hemiplegia in horses. Measurements were collected with the horses at rest, and trotting or pacing on a treadmill (6.38 degrees incline) at speeds of 4.2 and 7.0 m/s. Experimental protocols were performed after right common carotid artery exteriorization (baseline), after left recurrent laryngeal neurectomy (LRLN), and after left subtotal arytenoidectomy. At baseline, increasing treadmill speed progressively increased peak inspiratory and expiratory flow (VImax and VEmax, respectively), peak inspiratory and expiratory transupper airway pressure (PuI and PuE, respectively), respiratory frequency (f), tidal volume (VT), minute volume (VE), and heart rate. Inspiratory and expiratory times (TI and TE, respectively) and arterial oxygen tension (PaO2) decreased with increased treadmill speed; inspiratory and expiratory impedance (ZI and ZE, respectively) did not change. After LRLN, VImax, f, and PaO2 significantly (P less than 0.05) decreased at exercise, whereas PuI, TI, and ZI significantly increased. Minute volume decreased at exercise after LRLN, but the changes were not significant; LRLN had no effect on VEmax, PuE, ZE, heart rate, arterial carbon dioxide tension (PaCO2), or VT. Subtotal arytenoidectomy did not improve upper airway flow mechanics or blood gas measurements impaired by laryngeal hemiplegia.
采用上呼吸道气流力学和动脉血气测量方法，评估次全杓状软骨切除术治疗马诱导性左喉偏瘫的疗效。在马休息时，以及在跑步机（倾斜6.38度）上以4.2和7.0米/秒的速度小跑或踱步时进行测量。实验方案在右颈总动脉外置（基线）后、左喉返神经切除术（LRLN）后和左次全杓状软骨切除术后进行。在基线时，跑步机速度增加会使吸气和呼气峰值流量（分别为VImax和VEmax）、吸气和呼气经上呼吸道峰值压力（分别为PuI和PuE）、呼吸频率（f）、潮气量（VT）、分钟通气量（VE）和心率逐渐增加。吸气和呼气时间（分别为TI和TE）以及动脉血氧分压（PaO2）随跑步机速度增加而降低；吸气和呼气阻抗（分别为ZI和ZE）没有变化。LRLN后，运动时VImax、f和PaO2显著（P<0.05）降低，而PuI、TI和ZI显著增加。LRLN后运动时分钟通气量降低，但变化不显著；LRLN对VEmax、PuE、ZE、心率、动脉血二氧化碳分压（PaCO2）或VT没有影响。次全杓状软骨切除术并未改善因喉偏瘫受损的上呼吸道气流力学或血气测量结果。
