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基于自组装肽的纳米结构的生物医学应用。

Biomedical exploitation of self assembled peptide based nanostructures.

机构信息

Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur-721302, Índia.

出版信息

Curr Protein Pept Sci. 2013 Nov;14(7):580-7. doi: 10.2174/1389203711209070687.

Abstract

Nowadays, peptide based disease prevention is an important topic in biomedical science, which may radically change the traditional use of biomaterials and improve the life quality. Self-assembled nanostructured peptides have been receiving extreme attention in the drug delivery field due their high biocompatibility levels, better loading capacity, extended circulation and localization in required target site. This article focuses on the composition and synthesis of different forms of self-assembled peptide nanostructures as nanotubes, nanofibers, nanoparticles, nanotapes and nanogels. The most important properties for their self assembled mechanism and their biomedical applications are also discussed. Various potential applications of nanostructures peptide could be developed designed for therapeutic agent's delivery, biosensors, anticancerous and antimicrobial activities.

摘要

如今,基于肽的疾病预防是生物医学科学的一个重要课题,它可能从根本上改变生物材料的传统用途,提高生活质量。自组装纳米结构肽由于其高生物相容性、更好的载药能力、延长的循环和在所需靶位的定位,在药物输送领域受到了极大的关注。本文重点介绍了不同形式的自组装肽纳米结构,如纳米管、纳米纤维、纳米粒子、纳米带和纳米凝胶的组成和合成。还讨论了它们自组装机制和生物医学应用的最重要性质。可以开发设计各种用于治疗药物输送、生物传感器、抗癌和抗菌活性的纳米结构肽的潜在应用。

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