Onuki Yoshiyuki, Van Someren Eus J W, De Zeeuw Chris I, Van der Werf Ysbrand D
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands.
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, 1105 BA, Amsterdam, The Netherlands, Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research (CNCR), Neuroscience Campus Amsterdam, 1081 HV, Amsterdam, The Netherlands, Department of Medical Psychology, VU University Medical Center, 1081 HV, Amsterdam, The Netherlands.
Cereb Cortex. 2015 Feb;25(2):313-21. doi: 10.1093/cercor/bht221. Epub 2013 Aug 22.
The hippocampus and cerebellum play a role in the process of temporal memory formation. The interaction between these brain regions during the prediction of motor executions nevertheless remains unclear. Using fMRI, we show here that the hippocampus and cerebellum are co-activated during a timing-dependent task that requires accurate prediction timing of finger movements following preceding visual cues, but not during 2 control tasks: a reaction task requiring identical coordination of individual and combined fingers without predicting the motor timing, or an imagery task. In addition, functional connectivity analyses reveal that the hippocampus showed increased functional connectivity with the bilateral hemispheres of the cerebellum. These results suggest that hippocampal-cerebellar interplay occurs during spatio-temporal prediction of movements on the basis of visuomotor integration.
海马体和小脑在时间记忆形成过程中发挥作用。然而，在运动执行预测过程中，这些脑区之间的相互作用仍不清楚。通过功能磁共振成像（fMRI），我们在此表明，在一项依赖时间的任务中，海马体和小脑会共同激活，该任务要求根据先前的视觉线索准确预测手指运动的时间，但在两项对照任务中则不会：一项反应任务，要求单个手指和组合手指进行相同的协调，而无需预测运动时间；或者一项想象任务。此外，功能连接分析表明，海马体与小脑的双侧半球之间的功能连接增强。这些结果表明，基于视觉运动整合的运动时空预测过程中会发生海马体 - 小脑相互作用。
