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痴呆人群学习的神经基础:结合神经影像学的运动学习研究综述。

Neural Underpinnings of Learning in Dementia Populations: A Review of Motor Learning Studies Combined with Neuroimaging.

机构信息

University of California, Davis.

出版信息

J Cogn Neurosci. 2024 May 1;36(5):734-755. doi: 10.1162/jocn_a_02116.

Abstract

The intent of this review article is to serve as an overview of current research regarding the neural characteristics of motor learning in Alzheimer disease (AD) as well as prodromal phases of AD: at-risk populations, and mild cognitive impairment. This review seeks to provide a cognitive framework to compare various motor tasks. We will highlight the neural characteristics related to cognitive domains that, through imaging, display functional or structural changes because of AD progression. In turn, this motivates the use of motor learning paradigms as possible screening techniques for AD and will build upon our current understanding of learning abilities in AD populations.

摘要

本文旨在概述目前关于阿尔茨海默病(AD)中运动学习的神经特征以及 AD 的前驱阶段(高危人群和轻度认知障碍)的研究。本文旨在提供一个认知框架,以比较各种运动任务。我们将重点介绍与认知领域相关的神经特征,这些特征通过成像显示出由于 AD 进展而导致的功能或结构变化。反过来,这促使我们使用运动学习范式作为 AD 的可能筛查技术,并建立在我们对 AD 人群学习能力的现有理解之上。

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