Child and Adolescent Mental Health Services Clinical Academic Group, South London & Maudsley NHS Foundation Trust, Mapother House, De Crespigny Park, Denmark Hill, London SE5 8AF, United Kingdom.
Eur Psychiatry. 2013 Sep;28(7):423-6. doi: 10.1016/j.eurpsy.2013.05.008. Epub 2013 Aug 19.
Evidence for the recommendation to deliver Cognitive Behavioural Therapy (CBT) and Family Interventions (FI) to under-18s with psychosis derives from adult research, and no previous study has focused exclusively on an adolescent population. We evaluated adaptations of these therapies for adolescent inpatients with psychosis (CBTpA and FIpA), delivered as an adjunct to inpatient standard care (SC).
Thirty adolescent inpatients with psychotic symptoms on admission were sequentially allocated to receive CBTpA+SC (n=10); FIpA+SC (n=10) or SC alone (n=10). Psychotic symptoms and functioning were measured at admission and discharge.
Group comparisons did not reach conventional significance, but effect sizes in this pilot study showed a promising impact of CBTpA compared to SC alone, in reducing symptoms (ES: d=0.6), with smaller effect sizes for functioning (d=0.2) and for FIpA (symptoms, d=0.1 and functioning, d=0.4). There was no advantage of either additional treatment in reducing length of stay, but self-report satisfaction ratings were higher for both psychological therapies.
The study is the first to focus on an exclusively adolescent population, using appropriately adapted therapy protocols. Findings suggest that the interventions are feasible, acceptable and helpful for adolescents with psychosis. Larger randomised controlled trials are now needed.
向 18 岁以下精神病患者推荐认知行为疗法(CBT)和家庭干预(FI)的证据来源于成人研究,以前没有研究专门针对青少年人群。我们评估了这些疗法对精神病青少年住院患者(CBTpA 和 FIpA)的适应性,作为住院标准护理(SC)的辅助治疗。
30 名入院时出现精神病症状的青少年住院患者依次被分配接受 CBTpA+SC(n=10);FIpA+SC(n=10)或单独 SC(n=10)。入院和出院时测量精神病症状和功能。
组间比较未达到常规显著性水平,但这项初步研究的效应量表明,与单独 SC 相比,CBTpA 对减少症状(ES:d=0.6)有更有希望的影响,对功能(d=0.2)和 FIpA(症状,d=0.1 和功能,d=0.4)的影响较小。两种额外治疗在缩短住院时间方面都没有优势,但两种心理治疗的自我报告满意度评分都更高。
这项研究是第一个专门针对青少年人群的研究,使用了适当调整的治疗方案。研究结果表明,这些干预措施对精神病青少年是可行的、可接受的和有益的。现在需要更大规模的随机对照试验。