结构生物学：蛇年揭示帕金蛋白的蜿蜒形状。
Structural Biology: Parkin's Serpentine Shape Revealed in the Year of the Snake.
机构信息
Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
出版信息
Curr Biol. 2013 Aug 19;23(16):R691-3. doi: 10.1016/j.cub.2013.07.039.
PMID:23968926
Abstract
Parkin is an E3 ubiquitin ligase, mutations in which are responsible for autosomal recessive juvenile parkinsonism. Recently, several structures of Parkin have been solved, revealing its serpentine shape and modes of auto-inhibition.
摘要
Parkin 是一种 E3 泛素连接酶，其突变导致常染色体隐性遗传少年型帕金森病。最近，已经解析了几种 Parkin 的结构，揭示了其蛇形形状和自身抑制模式。
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