College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Can J Neurol Sci. 2013 Sep;40(5):684-90. doi: 10.1017/s031716710001492x.
We investigated patient socio-demographic, clinical and functional factors predicting cholinesterase inhibitor discontinuation by patients presenting to a memory clinic in Saskatoon, Saskatchewan.
Data collection began in March 2004 at the Rural and Remote Memory Clinic where family physicians referred their non-institutionalized patients. Neurological and neuropsychological assessment, patient and caregiver questionnaires provided the socio-demographic, clinical and functional variables. Univariate logistic regression analysis was used to examine possible associations between each independent variable and the binary outcome variable of treatment discontinuation. Multivariate logistic regression was used to determine predictors of cholinesterase inhibitor discontinuation within six months of drug initiation.
Our sample consisted of the first 63 patients (60.3% female) for whom we prescribed a cholinesterase inhibitor. The mean age at clinic day was 74.56 years (SD=7.78). We found that years of formal education was the only variable significantly associated with cholinesterase inhibitor discontinuation by six months. The more years of formal education, the lower the rate of drug discontinuation by six months.
Likelihood of cholinesterase inhibitor discontinuation by six months was predicted by fewer years of formal education.
我们调查了萨斯喀彻温省萨斯卡通的记忆诊所就诊患者的社会人口统计学、临床和功能因素，这些因素预测了他们停止使用胆碱酯酶抑制剂。
数据收集始于 2004 年 3 月，在农村和远程记忆诊所，家庭医生将他们的非住院患者转介过来。神经学和神经心理学评估、患者和护理人员问卷调查提供了社会人口统计学、临床和功能变量。单变量逻辑回归分析用于检查每个独立变量与治疗中断的二项结果变量之间可能存在的关联。多变量逻辑回归用于确定在开始药物治疗后六个月内停止使用胆碱酯酶抑制剂的预测因素。
我们的样本包括了前 63 名（60.3%为女性）患者，我们为他们开了胆碱酯酶抑制剂。诊所就诊日的平均年龄为 74.56 岁（SD=7.78）。我们发现，受正规教育年限是与六个月内停止使用胆碱酯酶抑制剂唯一显著相关的变量。受正规教育年限越长，六个月内停药的比例越低。
受正规教育年限较少可预测六个月内停止使用胆碱酯酶抑制剂的可能性。
