偏头痛患者降钙素基因相关肽基因多态性。
Calcitonin gene related peptide gene polymorphism in migraine patients.
机构信息
Department of Neurology, Trakya University Medical Faculty.
出版信息
Can J Neurol Sci. 2013 Sep;40(5):722-5. doi: 10.1017/s0317167100014980.
OBJECTIVE
Calcitonin gene related peptide (CGRP), which has a vasodilator effect, is held responsible for neurogenic inflammation and vasodilatation of the cranial vessels in migraine pathophysiology. In this study, we investigated the association between alpha CGRP gene polymorphism (CALCA T-692C) and migraine.
MATERIAL AND METHODS
One hundred and thirty-four female migraineurs and 96 healthy female cases were enrolled in the study. The patient group was further subdivided into migraine with and without aura groups. The CALCA T-692C gene polymorphism was identified using polymerase chain reaction (PCR) technique and restriction fragment length polymorphism (RFLP).
RESULTS
The genotype and allele frequencies of CALCA T-692C gene polymorphism did not differ between the migraine and control groups. Between the migraine with and without aura subgroups, there was no difference. No association was seen between the CALCA T-692C gene polymorphisms and migraine attack severity and frequency.
CONCLUSION
Our study did not show any association between CALCA T-692C gene polymorphism and migraine.
目的
降钙素基因相关肽（CGRP）具有血管舒张作用，被认为是偏头痛发病机制中颅脑血管的神经源性炎症和血管舒张的原因。在这项研究中，我们研究了 alpha CGRP 基因多态性（CALCA T-692C）与偏头痛之间的关系。
材料和方法
研究纳入了 134 名女性偏头痛患者和 96 名健康女性作为对照组。根据有无先兆，偏头痛患者进一步分为偏头痛伴先兆组和偏头痛无先兆组。使用聚合酶链反应（PCR）技术和限制性片段长度多态性（RFLP）检测 CALCA T-692C 基因多态性。
结果
CALCA T-692C 基因多态性的基因型和等位基因频率在偏头痛组和对照组之间没有差异。在偏头痛伴先兆组和偏头痛无先兆组之间也没有差异。CALCA T-692C 基因多态性与偏头痛发作严重程度和频率之间也没有相关性。
结论
我们的研究没有显示 CALCA T-692C 基因多态性与偏头痛之间存在任何关联。
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