Saku K, Fujino M, Yamamoto K, Ying H, Tashiro N, Harada R, Okabe M, Arakawa K
Department of Internal Medicine, Fukuoka University School of Medicine, Japan.
Artery. 1990;17(5):271-80.
To investigate the cardiac function of WHHL rabbit (WHHL), an animal model of familial hypercholesterolemia, electrocardiography (ECG) and echocardiography (UCG) were taken from this species of homozygous type and normolipidemic Japanese White rabbits (controls). In WHHL, two of four had intraventricular conduction disturbances (IVCD) in ECG. UCG study showed that the ejection fraction significantly increased (p less than 0.05) and deceleration time was shortened (p less than 0.01) in WHHL compared to normal controls.
为研究家族性高胆固醇血症动物模型WHHL兔（WHHL）的心脏功能，对这种纯合型兔以及血脂正常的日本白兔（对照组）进行了心电图（ECG）和超声心动图（UCG）检查。在WHHL兔中，四只中有两只在心电图检查中出现了室内传导阻滞（IVCD）。超声心动图研究显示，与正常对照组相比，WHHL兔的射血分数显著增加（p<0.05），减速时间缩短（p<0.01）。
