van Niekerk J L, Demacker P N, Hendriks T, de Boer H H
Artery. 1985;12(4):263-76.
Aim of the present study was to compare an alimentary and a hereditary rabbit model for hypercholesterolemia. Serum lipids, serum lipoproteins and distribution and prevention of atherosclerotic plaque formation were studied in (1%) cholesterol-fed NZW rabbits and both heterozygous and homozygous WHHL rabbits. Cholesterol-fed NZW rabbits showed a hypercholesterolemia without hypertriglyceridemia, caused by accumulation of a spectrum of cholesterol ester-rich beta-migrating lipoproteins with a relatively low density. The WHHL rabbits displayed both a hypercholesterolemia with an elevation of LDL, and a hypertriglyceridemia. The hypertriglyceridemia in the WHHL homozygotes was due to accumulation of VLDL remnants and in the heterozygotes to a slight rise in normal pre-beta VLDL. Despite the pronounced quantitative and qualitative differences in lipoproteins, the location and extent of atherosclerotic plaques which had developed after 13 weeks cholesterol-rich diet in NZW rabbits and in 10 months old homozygous WHHL rabbits, was quite similar. Partial ileal bypass surgery lowered serum cholesterol in all three groups and also prevented atherogenesis.
本研究的目的是比较高胆固醇血症的食源性和遗传性兔模型。在喂食1%胆固醇的新西兰白兔以及杂合和纯合的WHHL兔中，研究了血脂、血清脂蛋白以及动脉粥样硬化斑块形成的分布和预防情况。喂食胆固醇的新西兰白兔出现了高胆固醇血症但无高甘油三酯血症，这是由一系列密度相对较低、富含胆固醇酯的β迁移脂蛋白的积累所致。WHHL兔既表现出高胆固醇血症伴低密度脂蛋白升高，又表现出高甘油三酯血症。WHHL纯合子中的高甘油三酯血症是由于极低密度脂蛋白残粒的积累，而杂合子中的高甘油三酯血症则是由于正常前β极低密度脂蛋白略有升高。尽管脂蛋白在数量和质量上存在明显差异，但在喂食富含胆固醇饮食13周后的新西兰白兔和10月龄纯合WHHL兔中，动脉粥样硬化斑块的位置和范围相当相似。部分回肠旁路手术降低了所有三组的血清胆固醇，也预防了动脉粥样硬化的发生。
