伤寒沙门氏菌口服疫苗株Ty21a的基因组序列。
Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.
作者信息
Xu Deqi, Cisar John O, Poly Frédéric, Yang Jinghua, Albanese Jason, Dharmasena Madushini, Wai Tint, Guerry Patricia, Kopecko Dennis J
机构信息
Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
出版信息
Genome Announc. 2013 Aug 22;1(4):e00650-13. doi: 10.1128/genomeA.00650-13.
Abstract
Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.
摘要
减毒伤寒沙门氏菌Typhi菌株Ty21a是控制伤寒热的一种重要疫苗，并作为递送异源抗原的口服载体。这种随机突变菌株的关键减毒特征仍存在疑问。基因组测序已揭示679个单核苷酸多态性（SNP），这将有助于确定导致Ty21a安全性和免疫原性的改变。
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