• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.伤寒沙门氏菌口服疫苗株Ty21a的基因组序列。
Genome Announc. 2013 Aug 22;1(4):e00650-13. doi: 10.1128/genomeA.00650-13.
2
Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever.表达人乳头瘤病毒16型L1的伤寒沙门氏菌Typhi Ty21a作为预防宫颈癌和伤寒热的潜在活疫苗。
Clin Vaccine Immunol. 2007 Oct;14(10):1285-95. doi: 10.1128/CVI.00164-07. Epub 2007 Aug 8.
3
Characterization of CD8(+) effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine.用伤寒沙门氏菌Ty21a伤寒疫苗免疫的志愿者中CD8(+)效应T细胞反应的特征分析
J Immunol. 2002 Aug 15;169(4):2196-203. doi: 10.4049/jimmunol.169.4.2196.
4
Stable Chromosomal Expression of Shigella flexneri 2a and 3a O-Antigens in the Live Salmonella Oral Vaccine Vector Ty21a.福氏志贺菌2a和3a O抗原在减毒活沙门氏菌口服疫苗载体Ty21a中的稳定染色体表达
Clin Vaccine Immunol. 2017 Dec 5;24(12). doi: 10.1128/CVI.00181-17. Print 2017 Dec.
5
Vi Capsular Polysaccharide Produced by Recombinant Serovar Paratyphi A Confers Immunoprotection against Infection by Serovar Typhi.重组甲型副伤寒 Vi 荚膜多糖对伤寒血清型感染具有免疫保护作用。
Front Cell Infect Microbiol. 2017 Apr 24;7:135. doi: 10.3389/fcimb.2017.00135. eCollection 2017.
6
Stable expression of Shigella sonnei form I O-polysaccharide genes recombineered into the chromosome of live Salmonella oral vaccine vector Ty21a.志贺氏菌血清型 1 型 O-多糖基因重组稳定表达于活的口服沙门氏菌疫苗载体 Ty21a 染色体中。
Int J Med Microbiol. 2013 Apr;303(3):105-13. doi: 10.1016/j.ijmm.2013.01.001. Epub 2013 Mar 7.
7
Improvement of the live vaccine strain Salmonella enterica serovar Typhi Ty21a for antigen delivery via the hemolysin secretion system of Escherichia coli.通过大肠杆菌溶血素分泌系统递送抗原对减毒活疫苗株肠炎沙门氏菌伤寒血清型Ty21a进行改造。
Int J Med Microbiol. 2009 Feb;299(2):109-19. doi: 10.1016/j.ijmm.2008.06.006. Epub 2008 Aug 15.
8
Live oral typhoid vaccine Salmonella Typhi Ty21a - a surrogate vaccine against non-typhoid salmonella?口服伤寒活疫苗伤寒沙门氏菌 Ty21a- 一种针对非伤寒沙门氏菌的替代疫苗？
Vaccine. 2012 Nov 26;30(50):7238-45. doi: 10.1016/j.vaccine.2012.10.002. Epub 2012 Oct 17.
9
Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years.伤寒疫苗株Ty21a 25年期间的遗传稳定性
Int J Med Microbiol. 2009 Apr;299(4):233-46. doi: 10.1016/j.ijmm.2008.09.003. Epub 2009 Jan 1.
10
Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers.载体预激发对表达幽门螺杆菌脲酶A和B的减毒活重组伤寒沙门氏菌Ty21a疫苗在人类志愿者中免疫原性的影响。
Vaccine. 2004 Jun 2;22(17-18):2273-7. doi: 10.1016/j.vaccine.2003.11.020.

引用本文的文献

1
The JMU-SalVac-System: A Novel, Versatile Approach to Oral Live Vaccine Development.JMU-SalVac系统：一种用于口服活疫苗开发的新颖、通用方法。
Vaccines (Basel). 2024 Jun 20;12(6):687. doi: 10.3390/vaccines12060687.
2
Non-Canonical Host Intracellular Niche Links to New Antimicrobial Resistance Mechanism.非经典宿主细胞内生态位与新的抗菌耐药机制相关。
Pathogens. 2022 Feb 8;11(2):220. doi: 10.3390/pathogens11020220.
3
Why Is Eradicating Typhoid Fever So Challenging: Implications for Vaccine and Therapeutic Design.为何根除伤寒热如此具有挑战性：对疫苗和治疗设计的启示
Vaccines (Basel). 2018 Jul 24;6(3):45. doi: 10.3390/vaccines6030045.
4
Identification of Five Novel Typhi-Specific Genes as Markers for Diagnosis of Typhoid Fever Using Single-Gene Target PCR Assays.利用单基因靶向PCR检测法鉴定五个新的伤寒特异性基因作为伤寒热诊断标志物
Biomed Res Int. 2016;2016:8905675. doi: 10.1155/2016/8905675. Epub 2016 Nov 15.
5
Development of an Acid-Resistant Salmonella Typhi Ty21a Attenuated Vector For Improved Oral Vaccine Delivery.开发一种耐酸伤寒沙门氏菌Ty21a减毒载体以改进口服疫苗递送
PLoS One. 2016 Sep 27;11(9):e0163511. doi: 10.1371/journal.pone.0163511. eCollection 2016.
6
Novel antigens for enterotoxigenic Escherichia coli vaccines.肠毒素性大肠杆菌疫苗的新型抗原。
Expert Rev Vaccines. 2014 May;13(5):631-9. doi: 10.1586/14760584.2014.905745. Epub 2014 Apr 4.

本文引用的文献

1
Stable expression of Shigella sonnei form I O-polysaccharide genes recombineered into the chromosome of live Salmonella oral vaccine vector Ty21a.志贺氏菌血清型 1 型 O-多糖基因重组稳定表达于活的口服沙门氏菌疫苗载体 Ty21a 染色体中。
Int J Med Microbiol. 2013 Apr;303(3):105-13. doi: 10.1016/j.ijmm.2013.01.001. Epub 2013 Mar 7.
2
Global trends in typhoid and paratyphoid Fever.全球伤寒和副伤寒流行趋势。
Clin Infect Dis. 2010 Jan 15;50(2):241-6. doi: 10.1086/649541.
3
Anthrax protective antigen delivered by Salmonella enterica serovar Typhi Ty21a protects mice from a lethal anthrax spore challenge.由伤寒沙门氏菌Ty21a菌株递送的炭疽保护性抗原可保护小鼠免受致命炭疽芽孢攻击。
Infect Immun. 2009 Apr;77(4):1475-82. doi: 10.1128/IAI.00828-08. Epub 2009 Jan 29.
4
Genetic stability of vaccine strain Salmonella Typhi Ty21a over 25 years.伤寒疫苗株Ty21a 25年期间的遗传稳定性
Int J Med Microbiol. 2009 Apr;299(4):233-46. doi: 10.1016/j.ijmm.2008.09.003. Epub 2009 Jan 1.
5
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.高通量测序为伤寒沙门氏菌的基因组变异和进化提供了见解。
Nat Genet. 2008 Aug;40(8):987-93. doi: 10.1038/ng.195. Epub 2008 Jul 27.
6
Core-linked LPS expression of Shigella dysenteriae serotype 1 O-antigen in live Salmonella Typhi vaccine vector Ty21a: preclinical evidence of immunogenicity and protection.痢疾志贺氏菌1型O抗原在伤寒沙门氏菌活疫苗载体Ty21a中的核心连接LPS表达：免疫原性和保护性的临床前证据
Vaccine. 2007 Aug 14;25(33):6167-75. doi: 10.1016/j.vaccine.2007.06.003. Epub 2007 Jun 26.
7
The global burden of typhoid fever.伤寒热的全球负担。
Bull World Health Organ. 2004 May;82(5):346-53.
8
Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and CT18.肠炎沙门氏菌伤寒血清型菌株Ty2和CT18的比较基因组学
J Bacteriol. 2003 Apr;185(7):2330-7. doi: 10.1128/JB.185.7.2330-2337.2003.
9
Molecular cloning and characterization of genes for Shigella sonnei form I O polysaccharide: proposed biosynthetic pathway and stable expression in a live salmonella vaccine vector.宋内志贺氏菌I型O多糖基因的分子克隆与特性分析：推测的生物合成途径及其在减毒活沙门氏菌疫苗载体中的稳定表达
Infect Immun. 2002 Aug;70(8):4414-23. doi: 10.1128/IAI.70.8.4414-4423.2002.
10
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.多重耐药性伤寒沙门氏菌血清型Typhi CT18的全基因组序列
Nature. 2001 Oct 25;413(6858):848-52. doi: 10.1038/35101607.

伤寒沙门氏菌口服疫苗株Ty21a的基因组序列。

Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a.

作者信息

Xu Deqi, Cisar John O, Poly Frédéric, Yang Jinghua, Albanese Jason, Dharmasena Madushini, Wai Tint, Guerry Patricia, Kopecko Dennis J

机构信息

Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.

出版信息

Genome Announc. 2013 Aug 22;1(4):e00650-13. doi: 10.1128/genomeA.00650-13.

DOI:10.1128/genomeA.00650-13
PMID:23969054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3751609/
Abstract

Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.

摘要

减毒伤寒沙门氏菌Typhi菌株Ty21a是控制伤寒热的一种重要疫苗，并作为递送异源抗原的口服载体。这种随机突变菌株的关键减毒特征仍存在疑问。基因组测序已揭示679个单核苷酸多态性（SNP），这将有助于确定导致Ty21a安全性和免疫原性的改变。