Nabavi M, Arshi S, Bahrami A, Aryan Z, Bemanian M H, Esmaeilzadeh H, Jalali F, Pousti S B, Rezaei N
Department of Allergy and Clinical Immunology, Hazrat Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Allergy and Clinical Immunology, Hazrat Rasoul-e-Akram Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Allergol Immunopathol (Madr). 2014 Sep-Oct;42(5):465-71. doi: 10.1016/j.aller.2013.06.007. Epub 2013 Aug 19.
This study was performed to investigate the serum level of interleukin (IL)-13, IL-4, and interferon (IFN)-γ in chronic rhinosinusitis with nasal polyps (CRSwNP) and subsequent inflammation pattern and comorbidities including asthma and aspirin intolerance.
A case-control study was conducted on 60 adult patients with CRSwNP with mean age of 37.7±12.7 (ranging from 18 to 70) years, and on 20 healthy controls. Serum levels of IL-13, IL-4, and IFN-γ were assessed, using enzyme-linked immunosorbent assay to be compared between case and control groups. Serum level of total immunoglobulin (Ig) E was also assessed in the patients with CRSwNP.
Serum level of IL-13 in the patients with CRSwNP was significantly higher than the controls (0.98±1.56 vs. 0.34±0.16 pg/ml, respectively, p=0.002). IL-4 and IFN-γ did not differ significantly between the two groups. Total IgE level was significantly increased in the patients with CRSwNP, compared to the normal values (301.43±516.54 IU/ml, p=0.033). Among the patients with CRSwNP, 12/60 (20%) had aspirin intolerance and 44/60 (73.3%) had asthma. IgE was also higher in asthmatics than non-asthmatics patients (364.9±586.6 vs. 126.7±135.7, respectively, p=0.015). Patients with aspirin intolerance had higher levels of IFN-γ (4.7±1.4 vs. 4.1±0.6, respectively, p=0.022).
IL-13 with high level of total IgE was observed in the patients with CRSwNP, which predisposes them to have concomitant asthma. IFN-γ seems to be down-regulated in the patients with CRSwNP, but could be over-expressed in the presence of aspirin intolerance.
本研究旨在调查伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）患者的血清白细胞介素（IL）-13、IL-4和干扰素（IFN）-γ水平，以及随后的炎症模式和合并症，包括哮喘和阿司匹林不耐受。
对60例平均年龄为37.7±12.7（范围为18至70）岁的成年CRSwNP患者和20例健康对照者进行了病例对照研究。使用酶联免疫吸附测定法评估IL-13、IL-4和IFN-γ的血清水平，以便在病例组和对照组之间进行比较。还对CRSwNP患者的总免疫球蛋白（Ig）E血清水平进行了评估。
CRSwNP患者的IL-13血清水平显著高于对照组（分别为0.98±1.56与0.34±0.16 pg/ml，p = 0.002）。两组之间的IL-4和IFN-γ没有显著差异。与正常值相比，CRSwNP患者的总IgE水平显著升高（301.43±516.54 IU/ml，p = 0.033）。在CRSwNP患者中，12/60（20%）有阿司匹林不耐受，44/60（73.3%）有哮喘。哮喘患者的IgE也高于非哮喘患者（分别为364.9±586.6与126.7±135.7，p = 0.015）。阿司匹林不耐受患者的IFN-γ水平较高（分别为4.7±1.4与4.1±0.6，p = 0.022）。
在CRSwNP患者中观察到高水平的总IgE伴IL-13，这使他们易患伴发哮喘。IFN-γ在CRSwNP患者中似乎下调，但在存在阿司匹林不耐受时可能过度表达。
