Department of Intensive Care Medicine, St Elisabeth Hospital, Tilburg, The Netherlands.
Am J Geriatr Psychiatry. 2013 Oct;21(10):935-7. doi: 10.1016/j.jagp.2013.01.068. Epub 2013 Aug 19.
To study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population.
527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available.
The incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOEε4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4-2.1). Delirium did not last longer in patients with an APOEε4 allele compared to patients without an APOEε4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5).
There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke.
研究载脂蛋白 E（APOEε4）ε4 等位基因与卒中人群谵妄之间的关系。
采用意识模糊评估法对 527 例连续卒中患者在入院后第 1 周内进行谵妄筛查。在 353 例患者中提取了基因组 DNA。
353 例患者中，卒中后谵妄发生率为 11.3%。APOEε4 与谵妄之间无相关性。即使在调整了 IQCODE、卒中定位、卒中亚型、卒中严重程度、感染和脑萎缩后，也未发现相关性（比值比：0.9；95%置信区间：0.4-2.1）。与无 APOEε4 等位基因的患者相比，携带 APOEε4 等位基因的患者谵妄持续时间无明显差异（中位数：5.6 天[范围：1-21]与中位数：4.6 天[范围：1-15]，p=0.5）。
在卒中后急性期，APOEε4 等位基因的存在与谵妄的发生之间无相关性。
