中风后急性期的谵妄与载脂蛋白 E 基因的作用。
Delirium in the acute phase after stroke and the role of the apolipoprotein E gene.
机构信息
Department of Intensive Care Medicine, St Elisabeth Hospital, Tilburg, The Netherlands.
出版信息
Am J Geriatr Psychiatry. 2013 Oct;21(10):935-7. doi: 10.1016/j.jagp.2013.01.068. Epub 2013 Aug 19.
OBJECTIVE
To study the association between the epsilon 4 allele of apolipoprotein E (APOEε4) and delirium in a stroke population.
METHODS
527 consecutive stroke patients were screened for delirium during the first week of admission with the confusion assessment method. In three hundred fifty-three patients genomic DNA isolation was available.
RESULTS
The incidence of delirium after stroke in the 353 patients was 11.3%. There was no association between APOEε4 and delirium. Even after adjustment for IQCODE, stroke localization, stroke subtype, stroke severity, infection, and brain atrophy no association was found (odds ratio: 0.9; 95% confidence interval: 0.4-2.1). Delirium did not last longer in patients with an APOEε4 allele compared to patients without an APOEε4 allele (median: 5.6 days [range: 1-21] versus median: 4.6 days [range: 1-15], p = 0.5).
CONCLUSION
There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke.
目的
研究载脂蛋白 E（APOEε4）ε4 等位基因与卒中人群谵妄之间的关系。
方法
采用意识模糊评估法对 527 例连续卒中患者在入院后第 1 周内进行谵妄筛查。在 353 例患者中提取了基因组 DNA。
结果
353 例患者中，卒中后谵妄发生率为 11.3%。APOEε4 与谵妄之间无相关性。即使在调整了 IQCODE、卒中定位、卒中亚型、卒中严重程度、感染和脑萎缩后，也未发现相关性（比值比：0.9；95%置信区间：0.4-2.1）。与无 APOEε4 等位基因的患者相比，携带 APOEε4 等位基因的患者谵妄持续时间无明显差异（中位数：5.6 天[范围：1-21]与中位数：4.6 天[范围：1-15]，p=0.5）。
结论
在卒中后急性期，APOEε4 等位基因的存在与谵妄的发生之间无相关性。
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