• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Delirium and Alzheimer disease: A proposed model for shared pathophysiology.

作者信息

Fong Tamara G, Vasunilashorn Sarinnapha M, Libermann Towia, Marcantonio Edward R, Inouye Sharon K

机构信息

Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Aging Brain Center, Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.

出版信息

Int J Geriatr Psychiatry. 2019 Jun;34(6):781-789. doi: 10.1002/gps.5088. Epub 2019 Mar 15.

DOI:10.1002/gps.5088
PMID:30773695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6830540/
Abstract
摘要

相似文献

1
Delirium and Alzheimer disease: A proposed model for shared pathophysiology.谵妄与阿尔茨海默病：一种关于共同病理生理学的模型设想
Int J Geriatr Psychiatry. 2019 Jun;34(6):781-789. doi: 10.1002/gps.5088. Epub 2019 Mar 15.
2
Do delirium and Alzheimer's dementia share specific pathogenetic mechanisms?谵妄和阿尔茨海默病性痴呆是否有共同的特定发病机制？
Dement Geriatr Cogn Disord. 1999 Sep-Oct;10(5):319-24. doi: 10.1159/000017162.
3
Preclinical Amyloid-β and Axonal Degeneration Pathology in Delirium.谵妄中的临床前淀粉样β蛋白与轴突退变病理学
J Alzheimers Dis. 2017;55(1):371-379. doi: 10.3233/JAD-160461.
4
Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum?路易体痴呆伴意识障碍：不同的诊断还是同一谱系的一部分？
J Neurol Neurosurg Psychiatry. 2015 Jan;86(1):50-9. doi: 10.1136/jnnp-2013-306389. Epub 2014 May 23.
5
Serum biomarkers for delirium.用于谵妄的血清生物标志物。
J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1281-6. doi: 10.1093/gerona/61.12.1281.
6
Cerebrospinal fluid in long-lasting delirium compared with Alzheimer's dementia.与阿尔茨海默病性痴呆相比，持续性谵妄患者的脑脊液变化。
J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1130-6. doi: 10.1093/gerona/glq090. Epub 2010 Jun 7.
7
Delirium in dementia.痴呆中的谵妄
Int J Geriatr Psychiatry. 1998 Jan;13(1):49-56. doi: 10.1002/(sici)1099-1166(199801)13:1<49::aid-gps733>3.0.co;2-4.
8
Elucidating the pathophysiology of delirium and the interrelationship of delirium and dementia.阐明谵妄的病理生理学以及谵妄与痴呆的相互关系。
J Gerontol A Biol Sci Med Sci. 2006 Dec;61(12):1277-80. doi: 10.1093/gerona/61.12.1277.
9
Delirium in Alzheimer disease.阿尔茨海默病中的谵妄
Alzheimer Dis Assoc Disord. 1997 Mar;11(1):16-20. doi: 10.1097/00002093-199703000-00004.
10
Post-operative delirium is associated with poor cognitive outcome and dementia.术后谵妄与认知预后不良和痴呆有关。
Dement Geriatr Cogn Disord. 2006;21(4):221-7. doi: 10.1159/000091022. Epub 2006 Jan 18.

引用本文的文献

1
Correlation of β2-microglobulin with postoperative delirium and 3-year mortality undergoing knee or hip replacement surgery: a prospective cohort study.β2微球蛋白与膝关节或髋关节置换术后谵妄及3年死亡率的相关性：一项前瞻性队列研究。
Front Med (Lausanne). 2025 Aug 5;12:1597764. doi: 10.3389/fmed.2025.1597764. eCollection 2025.
2
Relationship between telomere length and postoperative delirium: a single center prospective observational pilot study.端粒长度与术后谵妄之间的关系：一项单中心前瞻性观察性试点研究。
Sci Rep. 2025 Jul 8;15(1):24390. doi: 10.1038/s41598-025-10288-4.
3
Protocol and design of the REPOSE study: a double-blinded, randomised, placebo-controlled trial to evaluate the efficacy of suvorexant to improve postoperative sleep and reduce delirium severity in older patients undergoing non-cardiac surgery.

本文引用的文献

1
Fluid and imaging biomarkers for Alzheimer's disease: Where we stand and where to head to.用于阿尔茨海默病的液体和成像生物标志物：我们的现状和未来方向。
Exp Gerontol. 2018 Jul 1;107:169-177. doi: 10.1016/j.exger.2018.01.002. Epub 2018 Jan 4.
2
Review of the potential use of blood neuro-biomarkers in the diagnosis of mild traumatic brain injury.血液神经生物标志物在轻度创伤性脑损伤诊断中的潜在应用综述。
Clin Exp Emerg Med. 2017 Sep 30;4(3):121-127. doi: 10.15441/ceem.17.226. eCollection 2017 Sep.
3
Delirium in Older Persons: Advances in Diagnosis and Treatment.
REPOSE研究的方案与设计：一项双盲、随机、安慰剂对照试验，旨在评估苏沃雷生改善非心脏手术老年患者术后睡眠及减轻谵妄严重程度的疗效。
BMJ Open. 2025 Mar 13;15(3):e091099. doi: 10.1136/bmjopen-2024-091099.
4
Clinical and intracranial electrophysiological signatures of post-operative and post-ictal delirium.术后及发作后谵妄的临床及颅内电生理特征
Clin Neurophysiol. 2025 Mar;171:38-50. doi: 10.1016/j.clinph.2024.12.023. Epub 2025 Jan 20.
5
Orexin Receptor Antagonists for the Prevention and Treatment of Alzheimer's Disease and Associated Sleep Disorders.食欲素受体拮抗剂在预防和治疗阿尔茨海默病及相关睡眠障碍中的应用。
Drugs. 2024 Nov;84(11):1365-1378. doi: 10.1007/s40265-024-02096-3. Epub 2024 Oct 4.
6
How much risk does delirium represent for the development of dementia?: Retrospective cohort study from over 260,000 patients record in a solitary institution.谵妄对痴呆症的发展意味着多大风险？：一项基于一家机构中超过26万份患者记录的回顾性队列研究。
Front Psychiatry. 2024 Sep 13;15:1387615. doi: 10.3389/fpsyt.2024.1387615. eCollection 2024.
7
Common molecular and pathophysiological underpinnings of delirium and Alzheimer's disease: molecular signatures and therapeutic indications.谵妄和阿尔茨海默病的常见分子和病理生理学基础：分子特征和治疗指征。
BMC Geriatr. 2024 Aug 29;24(1):716. doi: 10.1186/s12877-024-05289-3.
8
Neutrophil-Lymphocytes Ratio as Potential Early Marker for Alzheimer's Disease.中性粒细胞与淋巴细胞比值可作为阿尔茨海默病的早期潜在标志物。
Mediators Inflamm. 2024 Jun 30;2024:6640130. doi: 10.1155/2024/6640130. eCollection 2024.
9
Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis.在一项为期3年的回顾性分析中，血清神经丝轻链蛋白（NFL）和tau蛋白与谵妄相关，但血清泛素羧基末端水解酶L1（UCHL-1）和胶质纤维酸性蛋白（GFAP）或脑脊液中的突触结合蛋白25（SNAP-25）、神经元五肽2（NPTX2）或可溶性触发受体表达于髓细胞2（sTREM2）与谵妄不相关。
Front Neurol. 2024 Mar 19;15:1356575. doi: 10.3389/fneur.2024.1356575. eCollection 2024.
10
Exploring the Pathophysiology of Delirium: An Overview of Biomarker Studies, Animal Models, and Tissue-Engineered Models.探索谵妄的病理生理学：生物标志物研究、动物模型和组织工程模型概述。
Anesth Analg. 2023 Dec 1;137(6):1186-1197. doi: 10.1213/ANE.0000000000006715. Epub 2023 Oct 18.
老年人谵妄：诊断与治疗进展
JAMA. 2017 Sep 26;318(12):1161-1174. doi: 10.1001/jama.2017.12067.
4
Cerebrospinal Fluid Apolipoprotein E Levels in Delirium.谵妄患者脑脊液中载脂蛋白E水平
Dement Geriatr Cogn Dis Extra. 2017 Jul 11;7(2):240-248. doi: 10.1159/000477847. eCollection 2017 May-Aug.
5
NeurimmiRs and Postoperative Delirium in Elderly Patients Undergoing Total Hip/Knee Replacement: A Pilot Study.老年患者全髋关节/膝关节置换术后的神经微小RNA与术后谵妄：一项初步研究
Front Aging Neurosci. 2017 Jun 23;9:200. doi: 10.3389/fnagi.2017.00200. eCollection 2017.
6
High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery.高C反应蛋白可预测非心脏大手术后谵妄的发生率、持续时间及症状严重程度。
J Am Geriatr Soc. 2017 Aug;65(8):e109-e116. doi: 10.1111/jgs.14913. Epub 2017 May 26.
7
Ubiquitin C-terminal hydrolase-L1 (UCH-L1) as a therapeutic and diagnostic target in neurodegeneration, neurotrauma and neuro-injuries.泛素羧基末端水解酶-L1（UCH-L1）作为神经退行性疾病、神经创伤和神经损伤中的治疗和诊断靶点。
Expert Opin Ther Targets. 2017 Jun;21(6):627-638. doi: 10.1080/14728222.2017.1321635. Epub 2017 Apr 27.
8
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease.阿尔茨海默病患者血浆神经丝轻链与神经退行性变的关联
JAMA Neurol. 2017 May 1;74(5):557-566. doi: 10.1001/jamaneurol.2016.6117.
9
Cognitive impairment and BDNF serum levels.认知障碍与脑源性神经营养因子血清水平
Neurol Neurochir Pol. 2017 Jan-Feb;51(1):24-32. doi: 10.1016/j.pjnns.2016.10.001. Epub 2016 Oct 21.
10
MicroRNAs as Peripheral Biomarkers in Aging and Age-Related Diseases.微小RNA作为衰老及衰老相关疾病的外周生物标志物
Prog Mol Biol Transl Sci. 2017;146:47-94. doi: 10.1016/bs.pmbts.2016.12.013. Epub 2017 Feb 8.