Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, United States.
Curr Opin Cell Biol. 2013 Dec;25(6):730-4. doi: 10.1016/j.ceb.2013.07.013. Epub 2013 Aug 19.
The circadian clock governs biological timekeeping on a systemic level, helping to regulate and maintain physiological processes, including endocrine and metabolic pathways with a periodicity of 24-hours. Disruption within the circadian clock machinery has been linked to numerous pathological conditions, including cancer, suggesting that clock-dependent regulation of the cell cycle is an essential control mechanism. This review will highlight recent advances on the 'gating' controls of the circadian clock at various checkpoints of the cell cycle and also how the cell cycle can influence biological rhythms. The reciprocal influence that the circadian clock and cell cycle exert on each other suggests that these intertwined biological circuits are essential and multiple regulatory/control steps have been instated to ensure proper timekeeping.
生物钟在系统水平上控制着生物的时间节奏，有助于调节和维持生理过程，包括具有 24 小时周期性的内分泌和代谢途径。生物钟机制的破坏与许多病理状况有关，包括癌症，这表明生物钟对细胞周期的调节是一种重要的控制机制。本综述将重点介绍生物钟在细胞周期各个检查点的“门控”控制的最新进展，以及细胞周期如何影响生物节律。生物钟和细胞周期相互施加的相互影响表明，这些相互交织的生物回路是必不可少的，并且已经建立了多个调节/控制步骤以确保正确的计时。
