Biological Systems Control Team, Chemical Biology Project, Research and Development Department, Biomedicinal Information Research Center, National of Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo, 135-0064, Japan.
Curr Diab Rep. 2013 Apr;13(2):223-8. doi: 10.1007/s11892-012-0354-8.
Homeostatic systems have adapted to respond to the diurnal light/dark cycle. Numerous physiological pathways, including metabolism, are coordinated by this 24-h cycle. Animals with mutations in clock genes show abnormal glucose and lipid metabolism, indicating a critical relationship between the circadian clock and metabolism. Energy homeostasis is achieved through circadian regulation of the expression and activity of several key metabolic enzymes. Temporal organization of tissue metabolism is coordinated by reciprocal cross-talk between the core clock mechanism and key metabolic enzymes and transcriptional activators. The aim of this review is to define the role of the circadian clock in the regulation of insulin sensitivity by describing the interconnection between the circadian clock and metabolic pathways.
稳态系统已经适应了昼夜光/暗循环的变化。许多生理途径，包括新陈代谢，都受到这个 24 小时周期的协调。时钟基因突变的动物表现出异常的葡萄糖和脂质代谢，这表明生物钟与代谢之间存在着关键关系。通过对几种关键代谢酶的表达和活性的昼夜调节，实现能量稳态。组织代谢的时间组织是通过核心时钟机制和关键代谢酶和转录激活剂之间的相互交流来协调的。本文旨在通过描述生物钟与代谢途径之间的联系，来定义生物钟在调节胰岛素敏感性中的作用。
