从进食到饥饿转变过程中心脏、膈肌和骨骼肌中的葡萄糖利用情况。
Glucose utilization in heart, diaphragm and skeletal muscle during the fed-to-starved transition.
作者信息
Holness M J, Sugden M C
机构信息
Department of Biochemistry, London Hospital Medical College, U.K.
出版信息
Biochem J. 1990 Aug 15;270(1):245-9. doi: 10.1042/bj2700245.
Abstract
The progressive effects of starvation on muscle glucose utilization were studied in the conscious resting rat. High rates of glucose uptake and phosphorylation in constantly working cardiothoracic (heart, diaphragm) and postural skeletal muscles (soleus, adductor longus) were maintained for at least 9 h of starvation. A rapid decline in cardiac glucose utilization was observed during the period 9-24 h of starvation, but for the other muscles the decline was more gradual. Consequently, even after 24 h, rates of glucose utilization in these muscles remained quantitatively significant. In both cardiothoracic and working (postural) skeletal muscle, glucose uptake and phosphorylation and activity of the active form of pyruvate dehydrogenase exhibited differential sensitivities to starvation and also to acute elevation of fatty acid concentrations during acute (4-9 h) starvation, such that pyruvate oxidation was more rapidly suppressed than glucose uptake and phosphorylation. The results are discussed in relation to the role of the glucose/fatty acid cycle in glucose conservation during the fed-to-starved transition.
摘要
在清醒的静息大鼠身上研究了饥饿对肌肉葡萄糖利用的渐进性影响。在持续工作的心胸（心脏、膈肌）和姿势性骨骼肌（比目鱼肌、长收肌）中，高葡萄糖摄取率和磷酸化率在饥饿至少9小时内得以维持。在饥饿9至24小时期间观察到心脏葡萄糖利用率迅速下降，但其他肌肉的下降则较为缓慢。因此，即使在24小时后，这些肌肉中的葡萄糖利用率在数量上仍很显著。在心胸肌和工作（姿势性）骨骼肌中，葡萄糖摄取、磷酸化以及丙酮酸脱氢酶活性形式的活性对饥饿以及急性（4至9小时）饥饿期间脂肪酸浓度的急性升高均表现出不同的敏感性，使得丙酮酸氧化比葡萄糖摄取和磷酸化更快受到抑制。结合葡萄糖/脂肪酸循环在进食到饥饿转变过程中保存葡萄糖的作用对结果进行了讨论。
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本文引用的文献
1
Enzymic determination of D(-)-beta-hydroxybutyric acid and acetoacetic acid in blood.血液中D(-)-β-羟基丁酸和乙酰乙酸的酶法测定
Biochem J. 1962 Jan;82(1):90-6. doi: 10.1042/bj0820090.
2
Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.脂肪酸氧化抑制剂2-十四烷基缩水甘油酸对饥饿和四氧嘧啶糖尿病大鼠丙酮酸脱氢酶复合体活性的影响。
Biochem J. 1982 Oct 15;208(1):53-60. doi: 10.1042/bj2080053.
3
Reversible phosphorylation of pyruvate dehydrogenase in rat skeletal-muscle mitochondria. Effects of starvation and diabetes.大鼠骨骼肌线粒体中丙酮酸脱氢酶的可逆磷酸化。饥饿和糖尿病的影响。
Biochem J. 1984 Apr 15;219(2):635-46. doi: 10.1042/bj2190635.
4
Hindlimb muscle fiber populations of five mammals.五种哺乳动物的后肢肌纤维群体
J Histochem Cytochem. 1973 Jan;21(1):51-5. doi: 10.1177/21.1.51.
5
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6
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.一种在麻醉大鼠的骨骼肌和白色脂肪组织中定量体内葡萄糖利用的方法。
Biochem J. 1985 May 15;228(1):103-10. doi: 10.1042/bj2280103.
7
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8
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9
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J Clin Invest. 1988 Jul;82(1):293-9. doi: 10.1172/JCI113586.
10
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