Griffin Timothy M, Humphries Kenneth M, Kinter Michael, Lim Hui-Ying, Szweda Luke I
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Biochimie. 2016 May;124:74-83. doi: 10.1016/j.biochi.2015.10.013. Epub 2015 Oct 22.
A central feature of obesity-related cardiometabolic diseases is the impaired ability to transition between fatty acid and glucose metabolism. This impairment, referred to as "metabolic inflexibility", occurs in a number of tissues, including the heart. Although the heart normally prefers to metabolize fatty acids over glucose, the inability to upregulate glucose metabolism under energetically demanding conditions contributes to a pathological state involving energy imbalance, impaired contractility, and post-translational protein modifications. This review discusses pathophysiologic processes that contribute to cardiac metabolic inflexibility and speculates on the potential physiologic origins that lead to the current state of cardiometabolic disease in an obesogenic environment.
肥胖相关的心脏代谢疾病的一个核心特征是脂肪酸和葡萄糖代谢之间转换能力受损。这种损害，即所谓的“代谢灵活性受损”，发生在包括心脏在内的许多组织中。尽管心脏通常更喜欢代谢脂肪酸而非葡萄糖，但在能量需求较高的情况下无法上调葡萄糖代谢会导致一种涉及能量失衡、收缩功能受损和翻译后蛋白质修饰的病理状态。本综述讨论了导致心脏代谢灵活性受损的病理生理过程，并推测了在致肥胖环境中导致当前心脏代谢疾病状态的潜在生理根源。
