转化生长因子β2对大鼠肾系膜细胞中白细胞介素-1β和肿瘤坏死因子-α刺激的磷脂酶A2及前列腺素E2的合成具有不同的调节作用。
Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.
作者信息
Pfeilschifter J, Pignat W, Leighton J, Märki F, Vosbeck K, Alkan S
机构信息
Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
出版信息
Biochem J. 1990 Aug 15;270(1):269-71. doi: 10.1042/bj2700269.
Abstract
Treatment of rat glomerular mesangial cells with transforming growth factor beta 2 (TGF beta 2) stimulates prostaglandin E2 (PGE2) synthesis. Actinomycin D, cycloheximide and diclofenac attenuate the TGF beta 2-induced PGE2 formation. As shown previously, two proinflammatory cytokines, interleukin 1 beta (IL-1 beta) and tumour necrosis factor alpha (TNF alpha), are potent stimuli for PGE2 and phospholipase A2 secretion from mesangial cells. We report here that, whereas TGF beta 2 potentiates the IL-1 beta- and TNF alpha-evoked PGE2 production, it strongly inhibits the phospholipase A2 secretion induced by both cytokines. In addition, the inhibitory effect of TGF beta 2 on phospholipase A2 secretion is not due to the augmented PGE2 formation.
摘要
用转化生长因子β2（TGFβ2）处理大鼠肾小球系膜细胞可刺激前列腺素E2（PGE2）的合成。放线菌素D、放线菌酮和双氯芬酸可减弱TGFβ2诱导的PGE2形成。如先前所示，两种促炎细胞因子，白细胞介素1β（IL-1β）和肿瘤坏死因子α（TNFα），是系膜细胞分泌PGE2和磷脂酶A2的有效刺激物。我们在此报告，虽然TGFβ2增强了IL-1β和TNFα诱发的PGE2产生，但它强烈抑制这两种细胞因子诱导的磷脂酶A2分泌。此外，TGFβ2对磷脂酶A2分泌的抑制作用并非由于PGE2形成增加所致。
相似文献
1
Transforming growth factor beta 2 differentially modulates interleukin-1 beta- and tumour-necrosis-factor-alpha-stimulated phospholipase A2 and prostaglandin E2 synthesis in rat renal mesangial cells.转化生长因子β2对大鼠肾系膜细胞中白细胞介素-1β和肿瘤坏死因子-α刺激的磷脂酶A2及前列腺素E2的合成具有不同的调节作用。
Biochem J. 1990 Aug 15;270(1):269-71. doi: 10.1042/bj2700269.
2
Interleukin 1 and tumor necrosis factor synergistically stimulate prostaglandin synthesis and phospholipase A2 release from rat renal mesangial cells.白细胞介素1和肿瘤坏死因子协同刺激大鼠肾系膜细胞合成前列腺素并释放磷脂酶A2。
Biochem Biophys Res Commun. 1989 Mar 15;159(2):385-94. doi: 10.1016/0006-291x(89)90003-x.
3
Interleukin-1 beta and transforming growth factor-beta 2 enhance cytosolic high-molecular-mass phospholipase A2 activity and induce prostaglandin E2 formation in rat mesangial cells.白细胞介素-1β和转化生长因子-β2增强大鼠系膜细胞胞质高分子量磷脂酶A2活性并诱导前列腺素E2生成。
Eur J Biochem. 1992 Nov 15;210(1):169-76. doi: 10.1111/j.1432-1033.1992.tb17405.x.
4
Cyclic AMP mimics, but does not mediate, interleukin-1- and tumour-necrosis-factor-stimulated phospholipase A2 secretion from rat renal mesangial cells.环磷酸腺苷模拟但不介导白细胞介素 -1 和肿瘤坏死因子刺激大鼠肾系膜细胞分泌磷脂酶 A2。
Biochem J. 1991 Jan 1;273(Pt 1)(Pt 1):199-204. doi: 10.1042/bj2730199.
5
Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.细胞因子刺激大鼠系膜细胞分泌II型磷脂酶A2。其对培养的大鼠肾小球细胞花生四烯酸释放和前列腺素合成的作用。
J Clin Invest. 1993 Nov;92(5):2516-23. doi: 10.1172/JCI116860.
6
7
Involvement of a pertussis toxin-sensitive G-protein-coupled phospholipase A2 in lipopolysaccharide-stimulated prostaglandin E2 synthesis in cultured rat mesangial cells.百日咳毒素敏感的G蛋白偶联磷脂酶A2参与培养的大鼠系膜细胞中脂多糖刺激的前列腺素E2合成。
Biochim Biophys Acta. 1988 Dec 16;963(3):429-35. doi: 10.1016/0005-2760(88)90311-6.
8
Calcium dependency of prostaglandin E2 production in rat glomerular mesangial cells. Evidence that protein kinase C modulates the Ca2+-dependent activation of phospholipase A2.大鼠肾小球系膜细胞中前列腺素E2产生的钙依赖性。蛋白激酶C调节磷脂酶A2的钙依赖性激活的证据。
J Clin Invest. 1988 Jul;82(1):168-76. doi: 10.1172/JCI113566.
9
Interleukin 1 and tumor necrosis factor potentiate angiotensin II- and calcium ionophore-stimulated prostaglandin E2 synthesis in rat renal mesangial cells.白细胞介素1和肿瘤坏死因子可增强血管紧张素II和钙离子载体刺激的大鼠肾系膜细胞中前列腺素E2的合成。
Biochem Biophys Res Commun. 1990 Jun 15;169(2):585-95. doi: 10.1016/0006-291x(90)90371-s.
10
Cytokine- and forskolin-induced synthesis of group II phospholipase A2 and prostaglandin E2 in rat mesangial cells is prevented by dexamethasone.地塞米松可抑制细胞因子和福斯高林诱导的大鼠系膜细胞中II型磷脂酶A2和前列腺素E2的合成。
Biochem Biophys Res Commun. 1991 Oct 15;180(1):46-52. doi: 10.1016/s0006-291x(05)81252-5.
引用本文的文献
1
Role of transforming growth factor-β2 in, and apossible transforming growth factor-β 2 gene polymorphism as a marker of, renal dysfunction in essential hypertension: A study in Turkish patients.转化生长因子-β2在原发性高血压肾功能不全中的作用以及转化生长因子-β2基因多态性作为原发性高血压肾功能不全标志物的可能性：一项针对土耳其患者的研究
Curr Ther Res Clin Exp. 2005 Jul;66(4):266-78. doi: 10.1016/j.curtheres.2005.08.003.
2
The ω3-polyunsaturated fatty acid derivatives AVX001 and AVX002 directly inhibit cytosolic phospholipase A(2) and suppress PGE(2) formation in mesangial cells.ω3-多不饱和脂肪酸衍生物 AVX001 和 AVX002 可直接抑制细胞质型磷脂酶 A(2)，并抑制系膜细胞中 PGE(2)的形成。
Br J Pharmacol. 2012 Dec;167(8):1691-701. doi: 10.1111/j.1476-5381.2012.02114.x.
3
Bench-to-bedside review: Ventilation-induced renal injury through systemic mediator release--just theory or a causal relationship?从临床到病床：全身介质释放导致通气性肾损伤——仅仅是理论还是因果关系？
Crit Care. 2011 Aug 16;15(4):228. doi: 10.1186/cc10282.
4
Lysyl oxidase binds transforming growth factor-beta and regulates its signaling via amine oxidase activity.赖氨酰氧化酶与转化生长因子-β结合，并通过胺氧化酶活性调节其信号传导。
J Biol Chem. 2008 Dec 5;283(49):34229-40. doi: 10.1074/jbc.M803142200. Epub 2008 Oct 2.
5
FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.FTY720 通过转录机制抑制白细胞介素-1β诱导的肾系膜细胞中分泌型磷脂酶A2的表达。
Br J Pharmacol. 2007 Apr;150(7):943-50. doi: 10.1038/sj.bjp.0707171. Epub 2007 Feb 26.
6
Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.细胞因子对肾小球系膜细胞中II型磷脂酶A2表达的调控
Eur J Clin Pharmacol. 1993;44 Suppl 1:S7-9. doi: 10.1007/BF01428384.
7
Role of transforming growth factor-beta in maintenance of function of cultured neonatal cardiac myocytes. Autocrine action and reversal of damaging effects of interleukin-1.转化生长因子-β在培养的新生心肌细胞功能维持中的作用。自分泌作用及白细胞介素-1损伤效应的逆转。
J Clin Invest. 1992 Nov;90(5):2056-62. doi: 10.1172/JCI116087.
8
Inhibition of cytokine-induced nitric oxide production by transforming growth factor-beta 1 in human smooth muscle cells.转化生长因子-β1对人平滑肌细胞中细胞因子诱导的一氧化氮生成的抑制作用。
J Physiol. 1992 Aug;454:451-65. doi: 10.1113/jphysiol.1992.sp019273.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Plaque formation and isolation of pure lines with poliomyelitis viruses.脊髓灰质炎病毒的噬斑形成及纯系分离
J Exp Med. 1954 Feb;99(2):167-82. doi: 10.1084/jem.99.2.167.
3
Co-existence of vimentin and desmin type intermediate filaments in a subpopulation of adult rat vascular smooth muscle cells growing in primary culture.在原代培养中生长的成年大鼠血管平滑肌细胞亚群中波形蛋白和结蛋白类型中间丝的共存。
Exp Cell Res. 1982 May;139(1):87-94. doi: 10.1016/0014-4827(82)90321-4.
4
Purification and properties of a type beta transforming growth factor from bovine kidney.牛肾β型转化生长因子的纯化及性质
Biochemistry. 1983 Dec 6;22(25):5692-8. doi: 10.1021/bi00294a002.
5
Purification and initial characterization of a type beta transforming growth factor from human placenta.从人胎盘中纯化并初步鉴定一种β型转化生长因子。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3676-80. doi: 10.1073/pnas.80.12.3676.
6
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.人类血小板中的转化生长因子-β。主要储存部位的鉴定、纯化及特性分析。
J Biol Chem. 1983 Jun 10;258(11):7155-60.
7
Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures.培养物中[精氨酸]加压素对磷脂酶C的激活及前列腺素的合成
Biochem J. 1984 Nov 1;223(3):855-9. doi: 10.1042/bj2230855.
8
Hormonal modulation of glomerular function.肾小球功能的激素调节
Am J Physiol. 1983 Feb;244(2):F95-104. doi: 10.1152/ajprenal.1983.244.2.F95.
9
Endogenous suppression of neutral-active and calcium-dependent phospholipase A2 in human polymorphonuclear leukocytes.人多形核白细胞中中性活性和钙依赖性磷脂酶A2的内源性抑制
Biochim Biophys Acta. 1986 Nov 14;879(2):149-56. doi: 10.1016/0005-2760(86)90097-4.
10
Inflammatory effect of intradermal administration of soluble phospholipase A2 in rabbits.兔皮内注射可溶性磷脂酶A2的炎症效应
J Invest Dermatol. 1986 Apr;86(4):380-3. doi: 10.1111/1523-1747.ep12285639.
Zotero 插件