Steinmann U, Braun R, Sippel H, Estler C J
Institut für Pharmakologie und Toxikologie, Lehrstuhl für Toxikologie und Pharmakologie, Universität Erlangen, Nürnberg, Fed. Rep. of Germany.
Arzneimittelforschung. 1990 Jun;40(6):709-11.
The influence of intrahepatically infused naftidrofuryl (Dusodril) on indocyanine green (ICG) clearance was measured in healthy rats and rats with liver cirrhosis. In control rats naftidrofuryl reduced the ICG clearance from 0.043 to 0.029 mumol/min/g liver. Plasma half-life of ICG was prolonged significantly from 3.07 to 4.25 min. This was probably due to a depression of the cardiovascular function (blood pressure, heart-rate). In cirrhotic rats, the removal rate of ICG (0.050 mumol/min/g liver) was significantly lower and its half-life (7.61 min) longer than in normal rats. Probably the extraction rate for ICG was so low that naftidrofuryl did not further impair the reduced ICG clearance and half-life inspite of reduced diastolic blood pressure and heart rate.
在健康大鼠和肝硬化大鼠中测量了肝内输注萘呋胺酯（杜手足）对吲哚菁绿（ICG）清除率的影响。在对照大鼠中，萘呋胺酯使ICG清除率从0.043降至0.029μmol/分钟/克肝脏。ICG的血浆半衰期从3.07分钟显著延长至4.25分钟。这可能是由于心血管功能（血压、心率）受到抑制。在肝硬化大鼠中，ICG的清除率（0.050μmol/分钟/克肝脏）显著低于正常大鼠，其半衰期（7.61分钟）也更长。可能ICG的提取率非常低，以至于尽管舒张压和心率降低，萘呋胺酯仍未进一步损害降低的ICG清除率和半衰期。
