Center S A, Bunch S E, Baldwin B H, Hornbuckle W E, Tennant B C
Am J Vet Res. 1983 Apr;44(4):722-6.
Sulfobromophthalein (BSP) and indocyanine green (ICG) were given in single-dose IV injections to dogs and plasma disappearances were measured. The BSP was given at a dose of 5 mg/kg of body weight, and ICG was given at doses of 1.0 and 1.5 mg/kg. The half-life for BSP was 4.2 +/- 0.8 minutes, and for ICG at the 1.0 mg/kg dose, 9.0 +/- 2.0 minutes, and at the 1.5 mg/kg dose, 8.4 +/- 1.9 minutes. The disappearance rate (percentage per minute) for BSP was 17.0 +/- 3.2, and for ICG at the small dose level, 8.1 +/- 1.7, and at the large dose level, 8.7 +/- 2.2. The clearances (ml/min/kg) for BSP were 15.4 +/- 6.2 and for ICG at the small dose level, 3.7 +/- 0.7, and at the large dose level, 3.9 +/- 0.7. The 30-minute percentage retentions for BSP were 1.9 +/- 1.1 and for ICG at the small dose level, 14.7 +/- 5.0, and for ICG at the large dose level, 11.4 +/- 3.0. All of the differences between BSP and ICG means for these values measured were statistically significant (P less than 0.01). There were no significant differences between sexes or between the ICG doses for any of the values (P greater than 0.05).
向犬静脉注射单剂量的磺溴酞钠（BSP）和吲哚菁绿（ICG），并测定血浆清除率。BSP的给药剂量为5mg/kg体重，ICG的给药剂量为1.0mg/kg和1.5mg/kg。BSP的半衰期为4.2±0.8分钟，ICG剂量为1.0mg/kg时半衰期为9.0±2.0分钟，剂量为1.5mg/kg时半衰期为8.4±1.9分钟。BSP的清除率（每分钟百分比）为17.0±3.2，ICG小剂量水平时为8.1±1.7，大剂量水平时为8.7±2.2。BSP的清除率（ml/min/kg）为15.4±6.2，ICG小剂量水平时为3.7±0.7，大剂量水平时为3.9±0.7。BSP在30分钟时的潴留百分比为1.9±1.1，ICG小剂量水平时为14.7±5.0，大剂量水平时为11.4±3.0。所测这些数值中BSP与ICG均值之间的所有差异均具有统计学意义（P＜0.01）。对于任何数值，性别之间或ICG不同剂量之间均无显著差异（P＞0.05）。
