铜催化的吡咯的自由基C-H芳基化反应。
Copper-catalyzed free-radical C-H arylation of pyrroles.
作者信息
Honraedt Aurélien, Raux Marie-Audrey, Le Grognec Erwan, Jacquemin Denis, Felpin François-Xavier
机构信息
Université de Nantes, UFR Sciences et Techniques, UMR CNRS 6230, CEISAM, 2 rue de la Houssinière, BP 92208, 44322 Nantes Cedex 3, France.
出版信息
Chem Commun (Camb). 2014 May 25;50(40):5236-8. doi: 10.1039/c3cc45240a. Epub 2013 Aug 22.
PMID:23970307
Abstract
A room temperature copper-catalyzed radical arylation of pyrroles with anilines, through in situ generated aryl diazonium salts, has been developed under neutral conditions. Experimental and theoretical studies explain the crucial role of CaCO3 and the high regioselectivity observed.
摘要
已开发出一种在中性条件下，通过原位生成芳基重氮盐实现室温下铜催化吡咯与苯胺的自由基芳基化反应。实验和理论研究解释了碳酸钙的关键作用以及所观察到的高区域选择性。
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