血清反应阳性个体及血清反应阴性的高危个体中HIV-1的DNA扩增。
DNA amplification of HIV-1 in seropositive individuals and in seronegative at-risk individuals.
作者信息
Mariotti M, Lefrère J J, Noel B, Ferrer-Le-Coeur F, Vittecoq D, Girot R, Bosser C, Couroucé A M, Salmon C, Rouger P
机构信息
Institut National de Transfusion Sanguine, Université Pierre et Marie Curie, Paris, France.
出版信息
AIDS. 1990 Jul;4(7):633-7. doi: 10.1097/00002030-199007000-00004.
We assessed the HIV-1 status of seropositive and seronegative at-risk individuals by the polymerase chain reaction. Fifty-four out of 55 HIV-1-seropositive samples scored positive. However, HIV-1 proviral DNA was not detected in 16 seronegative homosexuals, 20 seronegative polytransfused haemophiliacs and 20 seronegative thalassaemic children, 20 individuals with isolated and persistent anti-core antibodies and 74 seronegative blood donors. These data indicate that positive HIV-1 DNA is likely to be an exceptional phenomenon in HIV-seronegative people.
我们通过聚合酶链反应评估了血清反应阳性和血清反应阴性的高危个体的HIV-1感染状况。55份HIV-1血清反应阳性样本中有54份检测结果呈阳性。然而，在16名血清反应阴性的同性恋者、20名血清反应阴性的多次输血血友病患者、20名血清反应阴性的地中海贫血儿童、20名有孤立且持续存在抗核心抗体的个体以及74名血清反应阴性的献血者中未检测到HIV-1前病毒DNA。这些数据表明，HIV-1 DNA阳性在HIV血清反应阴性人群中可能是一种罕见现象。
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